Analyzing Association of the XRCC3 Gene Polymorphism with Ovarian Cancer Risk

Table 3

Distribution of XRCC3 rs861539 genotype among ovarian cancer cases and controls included in the meta-analysis.

First; author	Year	Genotypes distribution; (Case source)			Genotypes distribution; (Controls source)			P-HWE; (Controls)	T2T2 versus T1T1		T1T2 versus T1T1		T1T2+T2T2 versus T1T1		T2T2 versus T1T1+T1T2
		T1T1	T1T2	T2T2	T1T1	T1T2	T2T2		OR (95% CI)	𝑃	OR (95% CI)	𝑃	OR (95% CI)	𝑃	OR (95% CI)	𝑃
Auranen [20]	2005	676	762	227	1712	1946	583	Yes	0.99 [0.83, 1.18]	0.88	0.99 [0.88, 1.12]	0.89	0.99 [0.88, 1.11]	0.87	0.99 [0.84, 1.17]	0.91
Beesley [26]	2007	291	339	101	288	351	108	Yes	0.93 [0.67, 1.27]	0.63	0.96 [0.77, 1.19]	0.69	0.95 [0.77, 1.17]	0.62	0.95 [0.71, 1.27]	0.72
Quaye [25]	2009	545	612	175	784	958	282	Yes	0.89 [0.72, 1.11]	0.31	0.92 [0.79, 1.07]	0.27	0.91 [0.79, 1.05]	0.21	0.93 [0.76, 1.14]	0.51
Webb [27]	2005	591	656	198	307	375	106	Yes	0.97 [0.74, 1.28]	0.83	0.91 [0.75, 1.10]	0.32	0.92 [0.77, 1.10]	0.37	1.02 [0.79, 1.32]	0.87
Total		2103	2369	701	3091	3630	1079		0.95 [0.85, 1.06]	0.37	0.95 [0.88, 1.03]	0.22	0.95 [0.88, 1.02]	0.19	0.97 [0.88, 1.08]	0.63
									Test  for; heterogeneity	𝑃=0.91	Test  for; heterogeneity	𝑃=0.88	Test  for; heterogeneity	𝑃=0.82	Test  for; heterogeneity	𝑃=0.77