Resistant Traits in Digital Organisms Do Not Revert Preselection Status despite Extended Deselection: Implications to Microbial Antibiotics Resistance
Table 2
Paired -test comparisons of average population fitness between deselections. Paired -tests were used instead of one-way ANOVA as the former is targeted towards testing the difference in 2 sets of data; hence, paired -test is a more appropriate test compared to one-way ANOVA. Our results show that there is no statistical difference between the average population fitness (from 25 replicates) from any 2 deselections, regardless of selection methods. However, the average population fitness from any deselection is significantly higher than control.
Paired -test comparisons
value
TS, loss-1 (generation 201 to 5200) versus loss-2 (generation 5401 to 10400)
0.617
TS, loss-1 (generation 201 to 5200) versus loss-3 (generation 10601 to 15400)
0.422
TS, loss-1 (generation 201 to 5200) versus loss-4 (generation 15801 to 20800)
0.656
TS, loss-2 (generation 5401 to 10400) versus loss-3 (generation 10601 to 15400)
0.061
TS, loss-2 (generation 5401 to 10400) versus loss-4 (generation 15801 to 20800)
0.683
TS, loss-3 (generation 10601 to 15400) versus loss-4 (generation 15801 to 20800)
0.158
FPS, loss-1 (generation 201 to 5200) versus loss-2 (generation 5401 to 10400)
0.980
FPS, loss-1 (generation 201 to 5200) versus loss-3 (generation 10601 to 15400)
0.975
FPS, loss-1 (generation 201 to 5200) versus loss-4 (generation 15801 to 20800)
0.483
FPS, loss-2 (generation 5401 to 10400) versus loss-3 (generation 10601 to 15400)
0.974
FPS, loss-2 (generation 5401 to 10400) versus loss-4 (generation 15801 to 20800)
0.522
FPS, loss-3 (generation 10601 to 15400) versus loss-4 (generation 15801 to 20800)
0.458
Loss-2 (generation 5401 to 10400), TS versus FPS
0.278
Loss-3 (generation 10601 to 15400), TS versus FPS
0.157
Loss-4 (generation 15801 to 20800), TS versus FPS
0.332
Control versus TS loss-2 (generation 5401 to 10400)
3.5 × 10−17
Control versus TS loss-3 (generation 10601 to 15400)
2.2 × 10−17
Control versus TS loss-4 (generation 15801 to 20800)
4.7 × 10−17
Control versus FPS loss-2 (generation 5401 to 10400)
1.7 × 10−25
Control versus FPS loss-3 (generation 10601 to 15400)
1.5 × 10−25
Control versus FPS loss-4 (generation 15801 to 20800)
