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BioMed Research International
Volume 2014 (2014), Article ID 650913, 6 pages
http://dx.doi.org/10.1155/2014/650913
Research Article

The Association between Platelet Count and Acute Phase Response in Chronic Spontaneous Urticaria

1Chair and Clinical Department of Internal Diseases, Dermatology and Allergology, Medical University of Silesia in Katowice, Ulica M. Curie-Skłodowskiej 10, 41-800 Zabrze, Poland
2Chair and Clinical Department of Otolaryngology, Medical University of Silesia in Katowice, Ulica M. Curie-Skłodowskiej 10, 41-800 Zabrze, Poland
3Department of Prosthetic Dentistry, Medical University of Silesia in Katowice, Plaça Akademicki 17, 41-902 Bytom, Poland
4Department of Pediatrics, Medical University of Silesia, Ulica 3-go Maja 13-15, 41-800 Zabrze, Poland

Received 14 February 2014; Accepted 18 May 2014; Published 16 June 2014

Academic Editor: Robert Movérare

Copyright © 2014 Alicja Kasperska-Zając et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The platelet parameters and C-reactive protein (CRP) are markers reflecting a systemic inflammatory response. Among those, CRP is one of the major proteins helpful in determination of severity/activity of chronic spontaneous urticaria (CSU). Aim. To determine relationships between platelet activation indices and serum concentration of CRP, the best marker of acute phase response, and their potential clinical use in CSU patients. Methods. Mean platelet volume (MPV), platelet distribution width (PDW), and platelet count as well as serum CRP concentration were measured in CSU patients, showing different degrees of urticarial severity, and in the healthy subjects. Results. No significant differences were found in MPV and PDW between CSU group and the healthy subjects. The platelet count was significantly higher in moderate-severe CSU than that of the controls and mild CSU patients. Serum CRP concentrations were significantly higher in CSU patients as compared with the healthy subjects and significantly correlated with the platelet count in CSU patients. Conclusions. Acute phase response in CSU is associated with the increased number of circulating platelets in patients with more severe symptoms. It seems that simple determination of platelet size indices is not a reliable indicator of CSU severity/activity.