In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication

Figure 4

TFO1 dose-response study for inhibiting FIPV replication. The concentrations of 50 nM and higher showed significant antiviral effects. 50 nM of circular TFO1 RNA was able to reduce viral copy number by 5-fold log₁₀ from 10¹⁴ to 10⁹, while 100 and 500 nM showed 4-fold reduction. Data are averages of 3 independent tests (mean ± SE). *Significantly different from FIPV-infected group.