IDH1/IDH2 but Not TP53 Mutations Predict Prognosis in Bulgarian Glioblastoma Patients

Table 1

Mutationsin IDH1, IDH2, and TP53 genes that were detected in 106 brain tumour patients.

Gene	Exon	Nucleotide change (amino acid change)		Number of patients with mutations (which are homozygous)	% mutations among all mutations in the gene
IDH1	Exon 4	c.395G>A	(R132H)	13 (1)	100 (7.7)
IDH2	Exon 4	c.386A>G	(K129R)	1 (1)	100
TP53	Exon 5	c.427G>A	(V143M)	1	2.4
		c.455C>T	(P152L)	1	2.4
		c.473G>A	(R158H)	1 (1)	2.4 (2.4)
		c.495G>C	(Q165H)	1	2.4
		c.523C>A	(R175S)	1	2.4
		c.524G>A	(R175H)	3	7.3
		c.535C>A	(H179N)	1	2.4
	Exon 6	c.584T>C	(I195T)	1	2.4
		c.632C>T	(T211I)	1	2.4
		c.643A>G	(S215G)	1	2.4
		c.659A>G	(Y220C)	1	2.4
	Exon 7	c.725G>A	(C242Y)	1	2.4
		c.733G>A	(G245S)	1	2.4
		c.742C>T	(R248W)	2	4.9
		c.773A>T	(E258V)	5	12.2
		c.775G>C	(D259H)	1	2.4
		del 716_21	(NA)	1	2.4
		del 759_61	(NA)	1	2.4
	Exon 8	c.799C>T	(R267W)	1	2.4
		c.806G>T	(S269I)	1	2.4
		c.817C>T	(R273C)	5 (3)	12.2 (7.3)
		c.821T>C	(V274A)	1	2.4
		c.841G>C	(D281H)	3	7.3
		c.844C>T	(R282W)	1	2.4
		c.847C>T	(R283C)	1	2.4
		c.850A>T	(T284S)	1	2.4
		c.853G>A	(E285K)	1	2.4
		c.857A>T	(E286V)	1	2.4