Research Article
IDH1/IDH2 but Not TP53 Mutations Predict Prognosis in Bulgarian Glioblastoma Patients
Table 3
Univariate and multivariate Cox analyses of the association between the features of the patients and overall survival.
| | Univariate Cox regression | Multivariate Cox regression | | HR | 95% CI | P | HR | 95% CI | P |
| Age (per year) | 1.048 | 1.029–1.067 | <0.001 | 1.039 | 1.018–1.061 | <0.001 | Gender (female versus male) | 0.884 | 0.575–1.361 | 0.576 | * | * | * | Secondary versus primary GBM | 0.271 | 0.123–0.597 | 0.001 | 0.487 | 0.215–1.106 | 0.086 | Resection (total versus others) | 0.854 | 0.559–1.303 | 0.463 | * | * | * | KPS (per 10 points) | 0.990 | 0.979–1.001 | 0.083 | * | * | * | IDH1/IDH2 (mutated versus nonmutated) | 0.274 | 0.124–0.604 | 0.001 | 0.237 | 0.157–0.791 | 0.011 | IDH1 SNP (SNP versus no SNP) | 0.745 | 0.343–1.617 | 0.456 | * | * | * | TP53 (mutated versus nonmutated) | 0.764 | 0.489–1.196 | 0.240 | * | * | * |
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Not included in multivariate analysis. HR: hazard ratio; CI: confidence interval; P: P value; IDH1 SNP refers to rs11554137.
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