Second-Generation Antipsychotics and Extrapyramidal Adverse Effects

Table 1

First- and second-generation antipsychotics and D2 antagonism.

Antagonistic D2 effect	First-generation antipsychotics	Second-generation antipsychotics
Low	Chlorpromazine Levomepromazine; Thioridazine	Clozapine; Quetiapine
Intermediate	Trifluoperazine; Perphenazine	Olanzapine
High	Haloperidol; Fluphenazine; Flupentixol	Risperidone; Ziprasidone; Aripiprazole (possible D2 agonism)