BioMed Research International / 2014 / Article / Tab 2

Clinical Study

Salvage Radiosurgery for Selected Patients with Recurrent Malignant Gliomas

Table 2

Patient treatment characteristics at recurrence.

ParametersNumber of patientsPatients treated by Stupp protocolPatients diagnosed with AAPatients diagnosed with GBM

Numbers of patients87514146
Gender
 Male
 Female

43 (49.4%)
44 (50.6%)

27 (52.9%)
24 (47.1%)

16 (39%)
25 (61%)

27 (58.7%)
19 (41.3%)
Age (years)
 median (range)

48.7 (18–78)

47 (26–71)

45 (18–78)

49.5 (26–78)
KPS
 Mean (range)
 KPS > 80
 KPS ≤ 80

83 (60–100)
40 (46%)
47 (50%)

90 (70–100)
28 (54.9%)
23 (45.1%)

90 (70–100)
22 (53.7%)
19 (46.3%)

80 (70–100)
18 (39.1%)
28 (60.9%)
RPA
 Mean (range)

4.1 (3–5)

4 (3–5)

4 (3–5)

4 (3–5)
Histology
 Anaplastic astrocytoma
 Glioblastoma

41 (47.1%)
46 (52.9%)

25 (49%)
26 (51%)

100%
0

0
100%
Time to recurrence (months)
 Mean (range)
 ≤8 months
 9–12 months
 >12 months

13.8 (4–61)
29 (33.3%)
30 (34.5%)
28 (32.2%)

11 (4–61)
14 (27.4%)
19 (27.3%)
18 (35.3%)

10 (4–61)
12 (29.3%)
15 (36.6%)
14 (34.1%)

10 (5–28)
17 (36.9%)
15 (32.6%)
13 (30.5%)
Tumour volume (cc)
 Mean (range)
 <3 cc
 4–7 cc
 >7 cc

8.7 (1–42.6)
29 (33.3%)
26 (29.9%)
32 (36.8%)

4 (0.36–34.1)
16 (31.4%)
22 (43.1%)
13 (25.5%)

5.2 (1–28)
12 (29.3%)
12 (29.3%)
17 (41.4%)

4 (0.05–34.1)
17 (37%)
14 (30.4%)
15 (32.6%)
Location
 Unifocal
 Multifocal
  
79 (90.8%)
8 (9.2%)

45 (88.2%)
6 (11.8%)

39 (95.1%)
2 (4.9%)

40 (87%)
6 (13%)
Dose radiosurgery
 Mean (range)
 Dose ≥ 18 Gy

18.01 Gy (14–20)
76 (87%)

18 Gy (16–20)
46 (90.2%)

18 (15–20)
35 (85.4%)

18 Gy (14–20)
41 (89.1%)
PTV margin
 Mean (range)
  0 mm
 1–3 mm
 >3 mm

1.67 mm (0–6)
43 (49.4%)
22 (25.3%)
22 (25.3%)

2 mm (0–6)
20 (39.2%)
10 (19.6%)
21 (41.2%)

2 mm (0–5)
19 (46.3%)
12 (29.3%)
10 (24.4%)

0 mm (0–6)
24 (52.2%)
10 (21.7%)
12 (26.1%)

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