BioMed Research International / 2014 / Article / Tab 5

Clinical Study

Salvage Radiosurgery for Selected Patients with Recurrent Malignant Gliomas

Table 5

Studies of SRS as treatment for recurrent high-grade gliomas.

Study Histological gradeMedian dose (Gy)Median volume (cm3)Median post-SRS survival (months)Prognostic factors

Chamberlain et al., 1994 [34]15IV13.4178NR
Hall et al., 1995 [35]25III–IV20286.5Age, KPS
Shrieve et al., 1995 [27]86IV1310.112Age, volume
Larson et al., 1996 [31]93IV166.516.4Age, grade, KPS, focality, and volume
Kondziolka et al., 1997 [36]42III–IV15.56.521Grade, volume
Cho et al., 1999 [23]46III–IV171011Age, grade, KPS, and volume
Ulm et al., 2005 [30]33III–IV15Location, RPA
Hsieh et al., 2005 [24]26IV1221.610KPS
Mahajan et al., 2005 [37]41IV4.711None
Combs et al., 2005 [21]32IV151010None
Kong et al., 2008 [13]114III–IV1610.626 (III)–13 (IV)Histology, volume
Patel et al., 2009 [18]26IV1810.48.5None
Biswas et al., 2009 [38]18IV158.45.3NR
Villavicencio et al., 2009 [25]26IV2077Extent of surgery
Pouratian et al., 2009 [22]26IV621.39.4KPS, PTV margin
Torok et al., 2011 [39]14IV246.9710NR
Maranzano et al., 2011 [40]13IV17.35.311Radiation dose
Cuneo et al., 2012 [29]63III/IV154.811Age, KPS, and bevacizumab
Park et al., 2012 [41]11IV1613.617.9None
Skeie et al., 2012 [17]51IV12.212.419 (from initial diagnosis)None
Martínez-Carrillo 201487III/IV18.018.710 (17 III–7.5 IV)KPS, RPA, histology, and PTV margin

NR: not reported.

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