Diagnosis, Treatment, and Outcome in Patients with Bleeding Peptic Ulcers and Helicobacter pylori Infections

Table 2

Incidence of rebleeding in Hp-eradicated patients with no maintenance acid-suppressive therapy among different studies [104].

Author	Year and; area	Ulcer type	Regimen	ER number	Mean F/U (M)	Rebleeding number (%)
Graham et al. [83]	1993,; USA	PU	Triple	17	12	0 (0%)
Labenz and Borsch [84]	1994,; Germany	PU	7 different protocols	42	17	0 (0%)
Jaspersen et al. [86]	1995,; Germany	PU	Dual	24	12	0 (0%)
Jaspersen et al. [109]	1995,; Germany	DU	Dual	29	12	1 (3.4%)
Rokkas et al. [85]	1995,; Greece	DU	Dual	13	12	0 (0%)
Santander et al. [87]	1996,; Spain	PU	Dual or triple	84	12	2 (2.3%)
Riemann et al. [88]	1997,; Germany	PU	Dual	42	19	2 (4.8%)
Sung et al. [89]	1997,; Hong Kong	PU	Triple	108	12	0 (0%)
Macri et al. [110]	1998,; Italy	DU	Quadruple	21	48	0 (0%)
Amendola et al. [111]	1999,; Argentina	PU	PPI 1-week regimen	42	24	0 (0%)
Gisbert et al. [112]	1999,; Spain	DU	Triple or dual	111	12	0 (0%)
Lai et al. [113]	2000,; Hong Kong	DU	Triple	41	53	2 (4.9%)
Vergara et al. [95]	2000,; Spain	PU	Triple or quadruple	93	27	0 (0%)
Pellicano et al. [114]	2001,; Italy	DU	Antibiotics	46	47	0 (0%)
Capurso et al. [115]	2001,; Italy	DU	Dual or triple	83	36	3 (3.3%)
Arkkila et al. [96]	2003,; Finland	PU	Quadruple or dual	176	12	2 (1.1%)
Liu et al. [101]	2003,; Taiwan	PU	Triple	26	56	0 (0%)
Horvat et al. [116]	2005,; Croatia	GU	Triple	43	12	1 (2.3%)
Gisbert et al. [104]	2012,; Spain	PU	Triple*	1000	39	5 (0.5%)

DU: duodenal ulcer; ER: eradication; F/U: followup; GU: gastric ulcer; PU: peptic ulcer (gastric or duodenal ulcer).
*Triple therapy first followed by 2nd-, 3rd-, or 4th-line treatment.