Antidiabetic Effect of Sida cordata in Alloxan Induced Diabetic Rats

Table 8

Effect of SCEE on pancreas, liver, and testis tissue protein, TBARS, H₂O₂, and nitrite content in alloxan induced diabetic animals.

Group	Protein	TBARS	H2O2	Nitrite content
	(𝜇g/mg tissue)	(nM/min/mg protein)	(nM/min/mg tissue)	(𝜇M/mL)
Pancreas
Normal control	5.0 ± 0.5^a	1.9 ± 0.2^d	5.5 ± 0.5^d	64.6 ± 2.0^e
Diabetic + glibenclamide	4.1 ± 0.3^bc	2.3 ± 0.2^cd	6.9 ± 0.4^cd	70.3 ± 0.6^de
Diabetic control	1.9 ± 0.2^e	4.9 ± 0.4^a	12.5 ± 0.5^a	102.3 ± 2.5^a
Diabetic + SCEE 150 mg/kg	2.6 ± 0.3^de	3.5 ± 0.2^b	9.7 ± 0.7^b	91.3 ± 3.0^b
Diabetic + SCEE 300 mg/kg	4.2 ± 0.3^b	2.6 ± 0.2^c	6.8 ± 0.3^cd	74.0 ± 1.7^cd
Liver
Normal control	6.6 ± 0.5^a	2.4 ± 0.1^e	6.5 ± 0.4^e	56.8 ± 1.9^d
Diabetic + glibenclamide	5.2 ± 0.4^b	2.9 ± 0.1^d	8.3 ± 0.7^cd	62.0 ± 1.8^cd
Diabetic control	2.2 ± 0.3^d	6.9 ± 0.3^a	12.9 ± 0.9^a	97.0 ± 3.6^a
Diabetic + SCEE 150 mg/kg	3.5 ± 0.4^c	4.7 ± 0.3^c	9.4 ± 0.5^bc	77.6 ± 2.5^b
Diabetic + SCEE 300 mg/kg	5.7 ± 0.3^ab	2.8 ± 0.1^de	7.5 ± 0.5^de	63.6 ± 0.6^cd
Testis
Normal control	4.7 ± 0.3^a	1.5 ± 0.2^c	5.3 ± 0.3^d	57.5 ± 2.7^d
Diabetic + glibenclamide	3.9 ± 0.2^b	2.0 ± 0.1^c	6.3 ± 0.6^cd	64.6 ± 1.5^cd
Diabetic control	1.7 ± 0.2^d	5.6 ± 0.3^a	11.4 ± 0.6^a	93.3 ± 4.1^a
Diabetic + SCEE 150 mg/kg	2.6 ± 0.4^c	3.8 ± 0.2^b	8.4 ± 0.5^b	82.2 ± 4.0^b
Diabetic + SCEE 300 mg/kg	4.2 ± 0.2^ab	2.1 ± 0.6^c	6.3 ± 0.3^cd	66.0 ± 1.7^c

Values expressed as means ± SD. Means ± SD with different superscript letters (a–d) within the column indicate significant difference (𝑃 < 0.05). SCEE: S. cordata ethyl acetate fraction.