Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 671532, 8 pages
http://dx.doi.org/10.1155/2014/671532
Research Article

Drug Release Kinetics and Front Movement in Matrix Tablets Containing Diltiazem or Metoprolol/λ-Carrageenan Complexes

1Department of Pharmacy, University of Parma, Parco delle Scienze 27/A, 43124 Parma, Italy
2Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
3Eratech Srl, Via Gandine 4, 29121 Piacenza, Italy

Received 26 February 2014; Revised 8 May 2014; Accepted 28 May 2014; Published 19 June 2014

Academic Editor: Shirui Mao

Copyright © 2014 Ruggero Bettini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Lankalapalli and V. R. M. Kolapalli, “Polyelectrolyte complexes: a review of their applicability in drug delivery technology,” Indian Journal of Pharmaceutical Sciences, vol. 71, no. 5, pp. 481–487, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. M. V. Rigo, D. A. Allemandi, and R. H. Manzo, “Swellable drug-polyelectrolyte matrices of drug-carboxymethylcellulose complexes. Characterization and delivery properties,” Drug Delivery, vol. 16, no. 2, pp. 108–115, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Takka, S. Rajbhandari, and A. Sakr, “Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 52, no. 1, pp. 75–82, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. A. F. Jimenez-Kairuz, J. M. Llabot, D. A. Allemandi, and R. H. Manzo, “Swellable drug-polyelectrolyte matrices (SDPM): characterization and delivery properties,” International Journal of Pharmaceutics, vol. 288, no. 1, pp. 87–99, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. M. C. Bonferoni, S. Rossi, F. Ferrari, M. Bertoni, G. K. Bolhuis, and C. Caramella, “On the employment of λ carrageenan in a matrix system. III. Optimization of a λ carrageenan-HPMC hydrophilic matrix,” Journal of Controlled Release, vol. 51, no. 2-3, pp. 231–239, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Konar and C. Kim, “Drug release from drug-polyanion complex tablets: poly(acrylamido-2-methyl-1-propanesulfonate sodium—co—methyl methacrylate),” Journal of Controlled Release, vol. 57, no. 2, pp. 141–150, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. N. Nujoma and C. J. Kim, “A designer's polymer as an oral drug carrier (tablet) with pseudo-zero-order release kinetics,” Journal of Pharmaceutical Sciences, vol. 85, no. 10, pp. 1091–1095, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. M. C. Bonferoni, S. Rossi, M. Tamayo, J. L. Pedraz, A. Dominguez-Gil, and C. Caramella, “On the employment of λ-carrageenan in a matrix system. I. Sensitivity to dissolution medium and comparison with Na carboxymethylcellulose and xanthan gum,” Journal of Controlled Release, vol. 26, no. 2, pp. 119–127, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. M. C. Bonferoni, S. Rossi, F. Ferrari, G. P. Bettinetti, and C. Caramella, “Characterization of a diltiazem-λ carrageenan complex,” International Journal of Pharmaceutics, vol. 200, no. 2, pp. 207–216, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. V. K. Gupta, M. Hariharan, T. A. Wheatley, and J. C. Price, “Controlled-release tablets from carrageenans: effect of formulation, storage and dissolution factors,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 51, no. 3, pp. 241–248, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Aguzzi, M. C. Bonferoni, M. R. Fortich, S. Rossi, F. Ferrari, and C. Caramella, “Influence of complex solubility on formulations based on lambda carrageenan and basic drugs,” AAPS PharmSciTech, vol. 3, no. 3, article E27, 2002. View at Google Scholar · View at Scopus
  12. M. C. Bonferoni, S. Rossi, F. Ferrari, and C. Caramella, “Development of oral controlled-tablet formulations based on diltiazem-carrageenan complex,” Pharmaceutical Development and Technology, vol. 9, no. 2, pp. 155–162, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Bettini, P. Colombo, G. Massimo, P. L. Catellani, and T. Vitali, “Swelling and drug release in hydrogel matrices: polymer viscosity and matrix porosity effects,” European Journal of Pharmaceutical Sciences, vol. 2, no. 3, pp. 213–219, 1994. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Bettini, P. Colombo, and N. A. Peppas, “Solubility effects on drug transport through pH-sensitive, swelling-controlled release systems: transport of theophylline and metoclopramide monohydrochloride,” Journal of Controlled Release, vol. 37, no. 1-2, pp. 105–111, 1995. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Colombo, R. Bettini, G. Massimo, P. L. Catellani, P. Santi, and N. A. Peppas, “Drug diffusion front movement is important in drug release control from swellable matrix tablets,” Journal of Pharmaceutical Sciences, vol. 84, no. 8, pp. 991–997, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. N. A. Peppas, “Analysis of Fickian and non-Fickian drug release from polymers.,” Pharmaceutica Acta Helvetiae, vol. 60, no. 4, pp. 110–111, 1985. View at Google Scholar · View at Scopus
  17. P. Colombo, P. L. Catellani, N. A. Peppas, L. Maggi, and U. Conte, “Swelling characteristics of hydrophilic matrices for controlled release. New dimensionless number to describe the swelling and release behavior,” International Journal of Pharmaceutics, vol. 88, no. 1–3, pp. 99–109, 1992. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Tamimi, J. Torres, R. Bettini et al., “Doxycycline sustained release from brushite cements for the treatment of periodontal diseases,” Journal of Biomedical Materials Research A, vol. 85, no. 3, pp. 707–714, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. M. C. Bonferoni, S. Rossi, F. Ferrari, E. Stavik, A. Pena-Romero, and C. Caramella, “Factorial analysis of the influence of dissolution medium on drug release from carrageenan-diltiazem complexes,” AAPS PharmSciTech, vol. 1, no. 2, article E15, 2000. View at Google Scholar
  20. S. Naim, B. Samuel, B. Chauhan, and A. Paradkar, “Effect of potassium chloride and cationic drug on swelling, erosion and release from kappa-carrageenan matrices,” AAPS PharmSciTech, vol. 5, no. 2, pp. 1–8, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Ferrero, A. Munoz-Ruiz, and M. R. Jimenez-Castellanos, “Fronts movement as a useful tool for hydrophilic matrix release mechanism elucidation,” International Journal of Pharmaceutics, vol. 202, no. 1-2, pp. 21–28, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Bettini, P. L. Catellani, P. Santi, G. Massimo, N. A. Peppas, and P. Colombo, “Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate,” Journal of Controlled Release, vol. 70, no. 3, pp. 383–391, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Kikuchi and K. Takayama, “Multivariate statistical approach to optimizing sustained-release tablet formulations containing diltiazem hydrochloride as a model highly water-soluble drug,” International Journal of Pharmaceutics, vol. 386, no. 1-2, pp. 149–155, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Prabakaran, P. Singh, P. Kanaujia, and S. P. Vyas, “Effect of hydrophilic polymers on the release of diltiazem hydrochloride from elementary osmotic pumps,” International Journal of Pharmaceutics, vol. 259, no. 1-2, pp. 173–179, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. U. Conte, P. Colombo, A. Gazzaniga, M. E. Sangalli, and A. La Manna, “Swelling-activated drug delivery systems,” Biomaterials, vol. 9, no. 6, pp. 489–493, 1988. View at Google Scholar · View at Scopus