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BioMed Research International
Volume 2014 (2014), Article ID 672094, 7 pages
Review Article

124Iodine: A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging

1Nuclear Medicine, University of Catanzaro “Magna Graecia”, Viale Europa, Localita Germaneto, 88100 Catanzaro, Italy
2Nuclear Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, No. 11, 70124 Bari, Italy

Received 28 December 2013; Accepted 18 April 2014; Published 8 May 2014

Academic Editor: Gianluca Valentini

Copyright © 2014 Giuseppe Lucio Cascini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


124Iodine (124I) with its 4.2 d half-life is particularly attractive for in vivo detection and quantification of longer-term biological and physiological processes; the long half-life of 124I is especially suited for prolonged time in vivo studies of high molecular weight compounds uptake. Numerous small molecules and larger compounds like proteins and antibodies have been successfully labeled with 124I. Advances in radionuclide production allow the effective availability of sufficient quantities of 124I on small biomedical cyclotrons for molecular imaging purposes. Radioiodination chemistry with 124I relies on well-established radioiodine labeling methods, which consists mainly in nucleophilic and electrophilic substitution reactions. The physical characteristics of 124I permit taking advantages of the higher PET image quality. The availability of new molecules that may be targeted with 124I represents one of the more interesting reasons for the attention in nuclear medicine. We aim to discuss all iodine radioisotopes application focusing on 124I, which seems to be the most promising for its half-life, radiation emissions, and stability, allowing several applications in oncological and nononcological fields.