¹²⁴Iodine: A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging

Table 1

Principal radiopharmaceutical labeled with ¹²⁴I.

Radiopharmaceutical	Chemical reaction	Function
^124I-MIBG	Nucleophilic exchange	Adrenergic activity
^124I-IAZA	Nucleophilic exchange	Hypoxia agent
^124I-IAZG	Nucleophilic exchange	Hypoxia agent
^124I-dRFIB	Nucleophilic exchange	Cell proliferation
^124I-IUdR	Direct electrophilic substitution on activated aromatic systems	Cell proliferation
^124I-labeled-hypericin	Direct electrophilic substitution on activated aromatic systems	Protein-kinase C
^124I-FIAU	Direct electrophilic substitution on activated aromatic systems	Herpes virus thymidine kinase
m-^124I-IPPM	Electrophilic radioiododestannylation reactions	Opioid receptors
^124I-IPQA	Electrophilic radioiododestannylation reactions	EGFR kinase activity
^124I-labeled-6-anilino-quinazoline deriv.	Electrophilic radioiododestannylation reactions	EGFR inhibitors
^124I-label.purpurinimide derivatives	Electrophilic radioiododestannylation reactions	Tumor imaging
^124I-label.CDK4/6 inhibitors	Electrophilic radioiododestannylation reactions	Cell proliferation