6-[¹⁸F]Fluoro-L-DOPA: A Well-Established Neurotracer with Expanding Application Spectrum and Strongly Improved Radiosyntheses

Table 2

Selected synthesis parameters using chiral auxiliaries or precursors.

Precursor	Time [min]	RCY [%]  ^18F-label.	RCY [%]  overall^a	SA [GBq/μmol]	ee [%]	Citation
16	100–110	51	12^b	n. d.	n. d.	Ding et al. ’90 [63]
15 or 16	120	n. d.	5–10	n. d.	50 (rac.)	Lemaire et al. ’91 [65]
15	110	n. d.	5–10^b	n. d.	83–96	Lemaire et al. ’93 [67]
15 or 16	120	20–35; ~50	3–5^b	n. d.	>99	Reddy et al. ’93 [68]
15	90	45 ± 5	17–29	>37	>96	Lemaire et al. ’94 [66]
15 or 16	125	n. d.	4-5^b	>74	98	Horti et al. ’95 [69]
15	85	~50	6–13^b	>7.4	98	Najafi ’95 [70]

aUnless otherwise stated, RCYs are given decay corrected (d. c.) and ^bnondecay corrected (n. d. c.).