Multiple Regression Analysis of mRNA-miRNA Associations in Colorectal Cancer Pathway

Table 2

Candidate genes frequently involved in CRC pathways (modified from [4]).

Gene name	Molecular function	CRC pathway
APC	Tumor suppressor gene	MSI and CIN
BAX	Apoptosis	MSI
BCL2	Antiapoptosis	MSI
DCC	Tumor suppressor gene	MSI and CIN
KRAS	Oncogene	MSI and CIN
MLH1	DNA mismatch repair	MSI
MSH2	DNA mismatch repair	MSI
MSH6	DNA mismatch repair	MSI
SMAD2	Tumor suppressor	MSI and CIN
SMAD4	Tumor suppressor	MSI and CIN
TGFBR2	Cell signaling	MSI and CIN
TP53	Tumor suppressor	MSI and CIN