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BioMed Research International
Volume 2014, Article ID 681596, 9 pages
Review Article

Nuclear Distribution of RNA Polymerase II and mRNA Processing Machinery in Early Mammalian Embryos

Laboratory of Cell Morphology, Institute of Cytology RAS, 4 Tikhoretsky Avenue, St. Petersburg 194064, Russia

Received 27 February 2014; Accepted 11 April 2014; Published 29 April 2014

Academic Editor: Hiromichi Matsumoto

Copyright © 2014 Irina O. Bogolyubova and Dmitry S. Bogolyubov. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Spatial distribution of components of nuclear metabolism provides a significant impact on regulation of the processes of gene expression. While distribution of the key nuclear antigens and their association with the defined nuclear domains were thoroughly traced in mammalian somatic cells, similar data for the preimplantation embryos are scanty and fragmental. However, the period of cleavage is characterized by the most drastic and dynamic nuclear reorganizations accompanying zygotic gene activation. In this minireview, we try to summarize the results of studies concerning distribution of major factors involved in RNA polymerase II-dependent transcription, pre-mRNA splicing mRNA export that have been carried out on early embryos of mammals.