Research Article

Dehydroabietic Acid Derivative QC2 Induces Oncosis in Hepatocellular Carcinoma Cells

Figure 7

Calpain-1 increased during oncosis and its inhibition attenuated the cytotoxicity of QC2. (a) Calpain-1 increased and gradually autolyzed into 76‚ÄČkDa fragments under QC2 treatment. (b) Significant change of cell viability was observed in SMMC-7721 cells when pretreated with the calpain inhibitor PD150606 ( ).
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(a)
682197.fig.007b
(b)