Dehydroabietic Acid Derivative QC2 Induces Oncosis in Hepatocellular Carcinoma Cells

Scheme 1

Synthetic route of compound QC2 (6) from dehydroabietic acid (1). Reagents and conditions: (a) (i) SOCl₂, benzene, reflux, and 3 h; (ii) MeOH, reflux, and 2 h; (b) CrO₃, AcOH, Ac₂O, 0°C to rt, and 12 h; (c) phenylhydrazine hydrochloride, EtOH, conc. HCl, reflux, and 3 h; (d) 1,2-dibromoethane, TBAB, NaOH, benzene, rt, and 12 h; (e) piperazine, K₂CO₃, KI, MeCN, reflux, and 8 h.