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BioMed Research International
Volume 2014, Article ID 684127, 11 pages
Review Article

Multiparametric MRI for Localized Prostate Cancer: Lesion Detection and Staging

David Geffen School of Medicine at UCLA, 200 Medical Plaza, No. 165-43, MC 695224, Los Angeles, CA 90095-6952, USA

Received 24 June 2014; Revised 28 September 2014; Accepted 3 October 2014; Published 30 November 2014

Academic Editor: Anup Patel

Copyright © 2014 Daniel J. A. Margolis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Multiparametric MRI of the prostate combines high-resolution anatomic imaging with functional imaging of alterations in normal tissue caused by neoplastic transformation for the identification and characterization of in situ prostate cancer. Lesion detection relies on a systematic approach to the analysis of both anatomic and functional imaging using established criteria for the delineation of suspicious areas. Staging includes visual and functional analysis of the prostate “capsule” to determine if in situ disease is, in fact, organ-confined, as well as the evaluation of pelvic structures including lymph nodes and bones for the detection of metastasis. Although intertwined, the protocol can be optimized depending on whether lesion detection or staging is of the highest priority.