Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 684383, 6 pages
http://dx.doi.org/10.1155/2014/684383
Research Article

Assessing Response Using -MIBI Early after Interstitial Chemotherapy with Carmustine-Loaded Polymers in Glioblastoma Multiforme: Preliminary Results

1Nuclear Medicine Service, Department of Medicine (DIMED), University Hospital, 35128 Padova, Italy
2Department of Neurosurgery, University Hospital, 35128 Padova, Italy
3Department of Medical Oncology 1, IOV, IRCCS, Venetian Oncology Institute, 35128 Padova, Italy
4Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University Hospital, 35128 Padova, Italy
5Neuroradiology Unit, University Hospital, 35128 Padova, Italy
6Biostatistics, Epidemiology and Public Health Unit, Department of Cardiac, Thoracic and Vascular Sciences, University Hospital, 35128 Padova, Italy

Received 13 February 2014; Accepted 4 March 2014; Published 27 March 2014

Academic Editor: Anna Luisa Di Stefano

Copyright © 2014 D. Cecchin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Perry, A. Chambers, K. Spithoff, and N. Laperriere, “Gliadel wafers in the treatment of malignant glioma: a systematic review,” Current Oncology, vol. 14, no. 5, pp. 189–194, 2007. View at Google Scholar
  2. S. Valtonen, U. Timonen, P. Toivanen et al., “Interstitial chemotherapy with carmustine-loaded polymers for high-grade gliomas: a randomized double-blind study,” Neurosurgery, vol. 41, no. 1, pp. 44–49, 1997. View at Google Scholar
  3. M. Westphal, D. C. Hilt, E. Bortey et al., “A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma,” Neuro-Oncology, vol. 5, no. 2, pp. 79–88, 2003. View at Google Scholar
  4. M. Westphal, Z. Ram, V. Riddle, D. Hilt, E. Bortey, and On behalf of the Executive Committee of the Gliadel Study Group, “Gliadel wafer in initial surgery for malignant glioma: long-term follow-up of a multicenter controlled trial,” Acta Neurochirurgica, vol. 148, no. 3, pp. 269–275, 2006. View at Google Scholar
  5. M. G. Hart, R. Grant, R. Gaside, G. Rogers, M. Somerville, and K. Stein, Chemotherapy Wafer for High-Grade Glioma (Review). The Cochrane Collaboration, John Wiley & Sons, New York, NY, USA, 2011.
  6. H. Brem, S. Piantadosi, P. C. Burger et al., “Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas,” The Lancet, vol. 345, no. 8956, pp. 1008–1012, 1995. View at Google Scholar
  7. B. R. Subach, T. F. Witham, D. Kondziolka, L. D. Lunsford, M. Bozik, and D. Schiff, “Morbidity and survival after 1, 3-bis(2-chloroethyl)-1-nitrosourea wafer implantation for recurrent glioblastoma: a retrospective case-matched cohort series,” Neurosurgery, vol. 45, no. 1, pp. 17–22, 1999. View at Google Scholar
  8. S. Ulmer, K. Spalek, A. Nabavi et al., “Temporal changes in magnetic resonance imaging characteristics of Gliadel wafers and of the adjacent brain parenchyma,” Neuro-Oncology, vol. 14, no. 4, pp. 482–490, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. R. R. Colen, P. O. Zinn, S. Hazany et al., “Magnetic resonance imaging appearance and changes on intracavitary gliadel wafer placement: a pilot study,” World Journal of Radiology, vol. 3, no. 11, pp. 266–272, 2011. View at Google Scholar
  10. A. Della Puppa, M. Rossetto, P. Ciccarino et al., “The first 3 months after BCNU wafers implantation in high-grade glioma patients: clinical and radiological considerations on a clinical series,” Acta Neurochirurgica, vol. 152, no. 11, pp. 1923–1931, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Cecchin, S. Chondrogiannis, A. D. Puppa et al., “Presurgical Tc99m-sestamibi brain SPET/CT versus SPET: a comparison with MRI and histological data in 33 patients with brain tumours,” Nuclear Medicine Communications, vol. 30, no. 9, pp. 660–668, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. F. P. Le Jeune, F. Dubois, S. Blond, and M. Steinling, “Sestamibi technetium-99m brain single-photon emission computed tomography to identify recurrent glioma in adults: 201 studies,” Journal of Neuro-Oncology, vol. 77, no. 2, pp. 177–183, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Cheng, Y. Li, Z. Xu, D. Li, and J. Wang, “A meta-analysis of Tc99m-MIBI SPECT for detection of recurrent glioma after radiation therapy,” Journal of Clinical Neuroscience, vol. 18, no. 3, pp. 307–312, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. F. P. Le Jeune, F. Dubois, S. Perez, S. Blond, and M. Steinling, “Technetium-99m sestamibi brain SPECT in the follow-up of glioma for evaluation of response to chemotherapy: first results,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 31, no. 5, pp. 714–719, 2004. View at Google Scholar · View at Scopus
  15. S. B. Perez, F. Le Jeune, F. Dubois, and M. Steinling, “Tc99m-MIBI brain SPECT as an indicator of the chemotherapy response of recurrent, primary brain tumors,” Nuclear Medicine Communications, vol. 28, no. 12, pp. 888–894, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Stupp, W. P. Mason, M. J. Van Den Bent et al., “Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma,” New England Journal of Medicine, vol. 352, no. 10, pp. 987–996, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. L. J. Sawyer, H. C. Starritt, S. C. Hiscock, and M. J. Evans, “Effective doses to patients from CT acquisitions on the GE Infinia Hawkeye: a comparison of calculation methods,” Nuclear Medicine Communications, vol. 29, no. 2, pp. 144–149, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. International Commission on Radiological Protection, “Radiation dose to patients from radiopharmaceuticals. ICRP publication 80,” Annals of the ICRP, vol. 3, p. 110, 1998. View at Google Scholar
  19. A. D. Puppa, M. Rossetto, P. Ciccarino et al., “Carmustine wafer implantation when surgical cavity is communicating with cerebral ventricles: technical considerations on a clinical series,” World Neurosurgery, vol. 76, no. 1-2, pp. 156–159, 2011. View at Publisher · View at Google Scholar · View at Scopus