Umbilical Cord Blood-Derived Stem Cells Improve Heat Tolerance and Hypothalamic Damage in Heat Stressed Mice

Table 2

Effects of heat exposure on hypothalamic levels of glutamate, lactate/pyruvate, glycerol, cerebral blood flow (CBF), and PO₂ in different groups of mice.

Treatment groups	Glutamate; (percentage of baseline)	Lactate/pyruvate; ratio	Glycerol; (percentage of baseline)	CBF (BPU)	PO2 (mmHg)
(1) Non-WBH mice	98±5	10±4	99±6	328±23	21±2
(2) Non-WBH mice treated with CD34^+; cells (1×10^5 cells/0.3 mL, i.v.)	100±6	12±5	98±7	307±24	21±3
(3) Heated mice treated with vehicle; saline (0.3 mL, i.v.)	196±22^a	231±32^a	198±16^a	162±11^a	10±1^a
(4) Heated mice treated with CD34^+ cells; (1×10^5 cells/0.3 mL, i.v.)	142±10^b	77±11^b	66±12^b	245±16^b	16±2^b

Samples were measured 4 hours after whole body heating (WBH) or the equivalent time period for non-heated group. ^acompared with non-WBH group (𝑃<0.01); ^bcompared with group 2 (𝑃<0.05). Data are means ± S.E.M. of 12 mice per group.