Umbilical Cord Blood-Derived Stem Cells Improve Heat Tolerance and Hypothalamic Damage in Heat Stressed Mice

Table 4

Effect of heat exposure on plasma levels of adrenocorticotrophic hormone (ACTH), corticosterone, tumor necrosis factor-𝛼 (TNF-𝛼), interleukin-10 (IL-10), and ICAM-1 for various groups of mice.

Treatment groups	ACTH; (pg·mL^−1)	Corticosterone; (ng·mL^−1)	TNF; (pg/mL)	IL-10; (pg/mL)	ICAM; (pg/mL)
(1) Non-WBH mice	372±79	32±19	10±6	5±3	9±4
(2) Non-WBH mice treated with CD34^+ cells	361±72	29±17	8±5	6±2	11±5
(3) WBH mice treated with saline	601±98^a	256±25^a	415±82^a	11±4^a	496±22^a
(4) WBH mice treated with CD34^+ cells	1764±116^b	643±30^b	37±6^b	83±11^b	67±18^b

Samples were measured 4 hours after whole body temperature (WBH; 41.2°C for 1 hour) or the equivalent time period for non-WBH group. ^acompared with non-WBH group (𝑃<0.01); ^bcompared with group 2 (𝑃<0.01). Data are means ± S.E.M. of 12 mice per group.