Research Article
Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia
Table 1
Summary of clinical and cytogenetic characteristics of the CLL cases included in the present study.
| | Patient characteristics () | |
| | Age (years) | 71 (47–92) | | Male | 30 (54.5%) | | Binet stage | | | A | 49 (89.1%) | | B | 5 (9.1%) | | C | 1 (1.8%) | | White blood cell count (×109/L) | 28.6 (7.30–240.0) | | Lymphocyte count (×109/L) | 23.2 (5.6–233) | | Hemoglobin (g/L) | 13.8 (9.1–16.8) | | Platelet count (9109/L) | 189.0 (20.0–373.0) | | Lactate dehydrogenase (U/L) | 358.0 (115–1086.0) | | -Microglobulin (mg/L) | 2.3 (1.0–6.54) | | ZAP70 positive* () | 22 (59.4%) | | CD38 positive* () | 12 (26.6%) | | FISH abnormalities | | | del(13q14) | 18 (32.7%) | | Trisomy 12 | 8 (14.5%) | | del(11q22) | 6 (11.0%) | | del(17p13) | 6 (11.0%) | | Normal FISH | 17 (31.0%) |
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Values are given as median (range) or number (%).
Positivity was considered when ZAP70 > 20% and CD38 > 30%.
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