Network Analysis of Neurodegenerative Disease Highlights a Role of Toll-Like Receptor Signaling

Figure 2

A toy model for analyzing the ND network based on shortest paths. An illustration showing how the shortest path and scores discussed in the report are calculated. Red, yellow, and green proteins are involved in three diseases A, B, and C correspondingly. Pink proteins 𝐴𝐵¹, and 𝐴𝐵² are shared between the two diseases A and B, while a blue protein 𝐴𝐶¹ is shared between the two diseases A and C. Considering protein 𝐴₁relating disease A as start protein and proteins 𝐶₂,𝐶₃,𝐶₄ relating disease C as end proteins, there are 𝑝₁=(𝐴₁→𝐶₂) and 𝑙=1;𝑝₂=(𝐴₁→𝐷₁→𝐶₄→𝐶₃)and 𝑙=3;𝑝₃=(𝐴₁→𝐷₁→𝐶₄) and 𝑙=2. The orange protein 𝐷₁ is a connector protein mediating the connection between two diseases B and C (𝐵₃→𝐷₁→𝐶₄).