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BioMed Research International
Volume 2014 (2014), Article ID 687978, 8 pages
Review Article

Growth Curves for Girls with Turner Syndrome

1Growth and Development Lab, Center for Investigation in Pediatrics (CIPED), School of Medicine, State University of Campinas (UNICAMP), 13083-887 Campinas, SP, Brazil
2Department of Pediatrics, School of Medicine, State University of Campinas (UNICAMP), 13083-887 Campinas, SP, Brazil

Received 25 March 2014; Revised 4 May 2014; Accepted 5 May 2014; Published 15 May 2014

Academic Editor: Flavia Prodam

Copyright © 2014 Fabio Bertapelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this study was to review the growth curves for Turner syndrome, evaluate the methodological and statistical quality, and suggest potential growth curves for clinical practice guidelines. The search was carried out in the databases Medline and Embase. Of 1006 references identified, 15 were included. Studies constructed curves for weight, height, weight/height, body mass index, head circumference, height velocity, leg length, and sitting height. The sample ranged between 47 and 1,565 (total = 6,273) girls aged 0 to 24 y, born between 1950 and 2006. The number of measures ranged from 580 to 9,011 (total = 28,915). Most studies showed strengths such as sample size, exclusion of the use of growth hormone and androgen, and analysis of confounding variables. However, the growth curves were restricted to height, lack of information about selection bias, limited distributional properties, and smoothing aspects. In conclusion, we observe the need to construct an international growth reference for girls with Turner syndrome, in order to provide support for clinical practice guidelines.