A Systematic Follow-Up of Mycobacterium tuberculosis Drug-Resistance and Associated Genotypic Lineages in the French Departments of the Americas over a Seventeen-Year Period
Table 1
Characteristics of the 1239 patients and the corresponding M. tuberculosis isolates; data on cases of resistant and multiresistant TB are specified in the respective columns.
Variables
Resistant TB (; 12.3%)
MDR-TB (; 2.1%)
total
a (%) ()
(%)
(%)
Gender
Male
101 (66.5)
0.651
13 (50.0)
0.147
786 (64.4)
Female
51 (33.5)
13 (50.0)
434 (35.6)
Unknown b
1
0
19
Age
<15 years
7 (4.8)
0.331
0
0.912
46 (3.9)
15–65 years
126 (85.7)
23 (88.5)
982 (82.9)
>65 years
14 (9.5)
3 (11.5)
156 (13.2)
Unknown b
6
0
55
Mean age
41.2
0.724
40.9
0.715
42.6
Originc
Guadeloupe
39 (25.5)
0.755
8 (30.8)
0.331
346 (27.9)
Martinique
23 (15.0)
1 (3.9)
177 (14.3)
French Guiana
91 (59.5)
17 (65.4)
716 (57.8)
HIV status
Positive
33 (51.6)
0.506
13 (65.0)
0.117
243 (47.5)
Negative
31 (48.4)
7 (35.0)
269 (52.5)
Unknown b
89
6
727
Bacteriologyd
Smear +/culture+
77 (53.5)
0.530
17 (65.4)
0.425
646 (56.2)
Smear −/culture+
67 (46.5)
9 (34.6)
503 (43.8)
Unknown b
9
0
90
Case characteristic
Persistent
11 (7.2)
0.007
7 (26.9)
<0.001
40 (3.2)
New case
142 (92.8)
19 (73.1)
1199 (96.8)
Lineaged
LAM
38 (24.8)
0.060
11 (42.3)
0.470
294 (23.7)
H
27 (17.7)
5 (19.2)
275 (22.2)
T
39 (25.5)
7 (26.9)
373 (30.1)
EAI
10 (6.5)
1 (3.9)
89 (7.2)
X
16 (10.5)
1 (3.9)
81 (6.5)
Others
23 (15.0)
1 (3.9)
127 (10.3)
Ntotal: total number of patients per variable. Number of patients/isolates for which this information was not available (excluded from calculations). Department where a given M. tuberculosis isolate has been obtained. LAM: Latin-American-Mediterranean; H: Haarlem; EAI: East-African-Indian; others: lineages/MTBC members accounting for <1.5% of the isolates (M. africanum, Beijing, M. bovis, CAS: Central-Asian, LAM10-CAM, LAM7-TUR, S) and phylogenetically undefined spoligotype profiles.