Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain

Figure 1

Chromosomal localization, exonic structure of alternative splice variants, and corresponding predicted protein isoforms of human PARK2. (a) Cytogenetic location of human PARK2 gene (6q26). (b) Exon organization map of the 21 human PARK2 splice variants currently known. Exons are represented as red bars. The size of introns (black line) is proportional to their length. The codes on left refer to gene identifiers reported in Table 1. (c) Predicted molecular architecture of PARK2 isoforms. Red boxes represent UBQ domain and blue boxes represent IBR domains.