ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury

<table>Versican cleavage in<i> Adamts4</i>−/− and<i> Adamts5</i>−/− mice following SCI. Versican fragments (~70 kDa) detected with the anti-DPEAAE antibody are seen in wild-type but not<i> Adamts4</i>−/− and<i> Adamts5</i>−/− mice 7 days after SCI (top panel, arrow). No versicanase activity was detected in sham-operated mice. <i>β</i>-Actin was used as a loading control (bottom panel).</table>

BioMed Research International

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Figure 2

Figure 2: ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury 