Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity
Figure 2
Morphological alterations of L. amazonensis promastigotes treated with LipoRHIC. ((a)-(b)) Untreated parasites; (a) L. amazonensis displaying the characteristic morphology of promastigotes; (b) promastigotes under mitotic process; ((c)-(d)) promastigotes treated with LipoRHIC liposomal at MIC concentration (5.5 μg/mL) for 24 h; (c) parasite showing “blebs” scattered over the flagella and rounded shape; (d) promastigotes under abnormal mitotic process, significant cell shrinkage and flagella reduced in size. Note the presence of pores on membrane surface; ((e)-(f)) promastigotes treated with LipoRHIC at a sub-MIC concentration (2.75 μg/mL); (e) some parasites showing “blebs” scattered over the plasma membrane (arrow); (f) parasite showing rounded shape. Bars = 1 μm.
