Induction of Apoptosis in Human Multiple Myeloma Cell Lines by Ebselen via Enhancing the Endogenous Reactive Oxygen Species Production

Figure 7

The damage of MM cells induced by ebselen was attenuated by NAC. (a) The cell viability decreased by 40 μM ebselen treatment for 24 hours was recovered by 15 mM NAC. (b) The increasing of ROS in MM cells treated with 40 μM for 4 hours was significantly reduced by 15 mM NAC. (c) 15 mM NAC resumed the MMP loss induced by 40 μM ebselen. (d) The apoptosis rate increased by 40 μM ebselen was attenuated by 15 mM NAC. Each value represents the mean ± SD from three independent experiments. *Significant difference compared to the control group (^∗𝑃<0.05, ^∗∗𝑃<0.01, one-way ANOVA with Scheffe’s test).

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