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BioMed Research International
Volume 2014, Article ID 697689, 9 pages
http://dx.doi.org/10.1155/2014/697689
Research Article

Association of vWA and TPOX Polymorphisms with Venous Thrombosis in Mexican Mestizos

1Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Avenida Instituto Politécnico Nacional 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico
2Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, México, DF, Mexico
3Laboratorio Biología Molecular Diagnóstica (BIMODI), Querétaro, QRO, Mexico
4Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Avenida Instituto Politécnico Nacional 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico
5Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación, Secretaría de Salud, México, DF, Mexico

Received 18 June 2014; Revised 15 August 2014; Accepted 18 August 2014; Published 31 August 2014

Academic Editor: Alice Santos-Silva

Copyright © 2014 Marco Antonio Meraz-Ríos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Venous thromboembolism (VTE) is a multifactorial disorder and, worldwide, the most important cause of morbidity and mortality. Genetic factors play a critical role in its aetiology. Microsatellites are the most important source of human genetic variation having more phenotypic effect than many single nucleotide polymorphisms. Hence, we evaluate a possible relationship between VTE and the genetic variants in von Willebrand factor, human alpha fibrinogen, and human thyroid peroxidase microsatellites to identify possible diagnostic markers. Methods. Genotypes were obtained from 177 patients with VTE and 531 nonrelated individuals using validated genotyping methods. The allelic frequencies were compared; Bayesian methods were used to correct population stratification to avoid spurious associations. Results. The vWA-18, TPOX-9, and TPOX-12 alleles were significantly associated with VTE. Moreover, subjects bearing the combination vWA-18/TPOX-12 loci exhibited doubled risk for VTE (95% CI = 1.02–3.64), whereas the combination vWA-18/TPOX-9 showed an OR = 10 (95% CI = 4.93–21.49). Conclusions. The vWA and TPOX microsatellites are good candidate biomarkers in venous thromboembolism diseases and could help to elucidate their origins. Additionally, these polymorphisms could become useful markers for genetic studies of VTE in the Mexican population; however, further studies should be done owing that this data only show preliminary evidence.