Nanoparticles with nonlipid interacting criteria, for example, long DNA aptamers , naturally diffuse through the type of toroidal pores where the opening region inside the pore consists of no pore inducing agents. The absence of pore inducing agents in the opening regions helps nanoparticles experience no considerable direct interactions with the agents. We have possibly observed such a type of pore induced by chemotherapy drugs. Beside chemotherapy drugs, a possible search for a better set of agents, for example, any natural or synthetic antimicrobial peptides or biomolecules which might create the type of pore as mentioned here, should be a meaningful investment. This will ensure a combination therapy at low cytotoxicity.