Aptamers as Both Drugs and Drug-Carriers

Table 1

Available aptamers currently under considerations.

Name of the aptamer	Primary target of the aptamer	Status
Macugen	VEGF	Approved [22]
AS1411	Nucleolin	Phase II [25, 26]
REG1	Factor Ixa	Phase II [29, 30]
EYE001	VEGFR	Phase II/III [47, 49]
LY2181308	Survivin mRNA	Phase III [50, 51]
E2F decoy oligonucleotides	Mesangial cells	Phase III [52, 53]
ARC1779	Vwf	Phase II [31]
NU172	Thrombin	Phase II [32]
E10030	PDGF	Phase II [23]
ARC1905	C5	Phase I [24]
NOX-E36	MCP-1	Phase I [27, 33]
NOX-A12	SDF-1	Phase I [27, 28]
NOX-H94	Hepcidin	Phase I [21]
BAX499/ARC19499	TFPI	Phase I [34, 35]
DNA aptamers	Thrombin	Research [11]
DNA aptamers	Phosphatidylserine (PS)	Research [11, 38] (see Section 2.4)