BioMed Research International / 2014 / Article / Tab 1

Review Article

Aptamers as Both Drugs and Drug-Carriers

Table 1

Available aptamers currently under considerations.

Name of the aptamerPrimary target of the aptamerStatus

MacugenVEGFApproved [22]
AS1411NucleolinPhase II [25, 26]
REG1Factor IxaPhase II [29, 30]
EYE001VEGFRPhase II/III [47, 49]
LY2181308Survivin mRNAPhase III [50, 51]
E2F decoy oligonucleotidesMesangial cells Phase III [52, 53]
ARC1779VwfPhase II [31]
NU172ThrombinPhase II [32]
E10030PDGFPhase II [23]
ARC1905C5Phase I [24]
NOX-E36MCP-1Phase I [27, 33]
NOX-A12SDF-1Phase I [27, 28]
NOX-H94HepcidinPhase I [21]
BAX499/ARC19499TFPIPhase I [34, 35]
DNA aptamersThrombinResearch [11]
DNA aptamers Phosphatidylserine (PS)Research [11, 38] (see Section 2.4)