Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia: Their Target Cells and Time Window

<table>Ligands in the EGF family interact with heteromeric or homomeric ErbB receptors in GABAergic, dopaminergic (DA), and glial cells. ErbB ligands include EGF, HB-EGF (heparin-binding EGF-like growth factor), TGF<i>α</i> (transforming growth factor alpha), amphiregulin, NRG1-6, and virokines (VGF, SPGF, MGF, etc.), which associate with these ErbB receptor complexes to evoke both EGF-like and NRG-like signals. ErbB1-4 selectivity of the virokines remains to be characterized. These virokines carry the EGF-like amino acid motif common to human EGF and NRG1alpha. VGF: vaccinia virus growth factor; SPGF: smallpox virus growth factor; MGF: myxoma virus growth factor.</table>

BioMed Research International

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Figure 2: Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia: Their Target Cells and Time Window 

Figure 2 | Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia: Their Target Cells and Time Window 