Figure 4: Neurobehavioral consequences following subcutaneous/intracerebral administration of EGF to neonatal, juvenile, and adult rats. Intracerebral administration to adult rats was achieved with cannula implantation to the stratum; EGF was subchronically supplied from an osmotic pump at the rate of 75 ng/h. There is a critical time window for the induction of behavioral deficits following peripheral EGF administration.