Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia: Their Target Cells and Time Window
Figure 5
Neonatal EGF treatment enhances and maintains collateral sprouting of dopaminergic fibers in the globus pallidus (GPe). Neonatal rats were subcutaneously challenged with EGF (1 mg/kg body/day) for 9 days and grown until adulthood. EGF-treated and vehicle-treated rats were subjected to immunohistochemistry at the adult stage. In comparison with the tyrosine hydroxylase staining in the striatum (left), immunoreactivity in the lateral area of the GPe is elevated in the EGF-treated rats. Scale bars = 1000 and 100 μm.
