Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia: Their Target Cells and Time Window

Table 1

Immediate and delayed effects of neonatal NRG1 and EGF administration.

		NRG1 Injection	EGF Injection
Behaviors	Sound startle	No change	No change
	Fear-learning	No change	No change
	Locomotor	No change	No change
	PPI	DECREASE	DECREASE
	Social behaviors	DECREASE	DECREASE
GABA	GAD 65/67	No change	(DECREASE)*
	PV	No change	(DECREASE)*
Glutamate	NR1 (GluN1)	No change	(DECREASE)*
	NR2 (GluN2)	No change	no change
	GluR1	(INCREASE)	(DECREASE)*
Dopamine	TH	INCREASE (cortex)	INCREASE (pallidus)
	DA	No change	INCREASE (pallidus)
	DOPAC	INCREASE (cortex)	INCREASE (pallidus)

∗represent transient changes during neonatal administration. GAD: glutamate decarboxylase; PV: parvalbumin; TH: tyrosine hydroxylase; DA: dopamine; DOPAC: 3,4-dihydroxy-phenylacetic acid. Statistical significance represents 𝑃<0.05.