Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia: Their Target Cells and Time Window

Table 2

Behavioral and neurochemical effects of persistent NRG1 and EGF overexpression from their transgenes.

		NRG-1 TG	EGF-TG
Behaviors	Sound startle	No change	No change
	Fear-learning	INCREASE	Modest decrease
	Locomotor	INCREASE	No change
	PPI	Modest decrease	DECREASE
	Social behaviors	DECREASE	DECREASE
GABA	GAD 65/67	No change	No change
	PV	INCREASE (cortex)	No change
Glutamate	NR1 (GluN1)	No change	No change*
	NR2 (GluN2)	No change	No change*
	GluR1 (GluA1)	No change	No change*
Dopamine	TH	DECREASE (cortex)	DECREASE (striatum)
	DAT	No change	No change
	DA	DECREASE (hippocampus)	INCREASE (accumbens)
	DOPAC	DECREASE (hippocampus)	INCREASE (accumbens)

∗represent effects on basal ganglia regions GAD: glutamate decarboxylase; PV: parvalbumin; TH: tyrosine hydroxylase; DA: dopamine; DAT: dopamine transporter; DOPAC: 3,4-dihydroxy-phenylacetic acid. Statistical significance represents 𝑃<0.05 and “modest” indicates marginal changes with 0.05<𝑃<0.10.