Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 698265, 10 pages
http://dx.doi.org/10.1155/2014/698265
Review Article

Intensive Insulin Therapy for Septic Patients: A Meta-Analysis of Randomized Controlled Trials

1School of Medicine, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, China
2Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou 310003, China
3Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou 310003, China
4Department of Surgery, Children’s Hospital, School of Medicine, Zhejiang University, Zhuganxiang 57, Hangzhou 310003, China

Received 7 January 2014; Accepted 18 March 2014; Published 18 June 2014

Academic Editor: Baoli Cheng

Copyright © 2014 Fang Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. C. Angus, W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M. R. Pinsky, “Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care,” Critical Care Medicine, vol. 29, no. 7, pp. 1303–1310, 2001. View at Google Scholar · View at Scopus
  2. G. Kumar, N. Kumar, A. Taneja et al., “Nationwide trends of severe sepsis in the 21st century (2000–2007),” Chest, vol. 140, no. 5, pp. 1223–1231, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. J. H. Taylor and G. J. Beilman, “Hyperglycemia in the intensive care unit: no longer just a marker of illness severity,” Surgical Infections, vol. 6, no. 2, pp. 233–245, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. S. E. Inzucchi, “Management of hyperglycemia in the hospital setting,” The New England Journal of Medicine, vol. 355, no. 18, pp. 1903–1911, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. J. S. Krinsley, “Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients,” Mayo Clinic Proceedings, vol. 78, no. 12, pp. 1471–1478, 2003. View at Google Scholar · View at Scopus
  6. L. Leonidou, M. Michalaki, A. Leonardou et al., “Stress-induced hyperglycemia in patients with severe sepsis: a compromising factor for survival,” The American Journal of the Medical Sciences, vol. 336, no. 6, pp. 467–471, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. K. M. Dungan, S. S. Braithwaite, and J.-C. Preiser, “Stress hyperglycaemia,” The Lancet, vol. 373, no. 9677, pp. 1798–1807, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. K. C. McCowen, A. Malhotra, and B. R. Bistrian, “Stress-induced hyperglycemia,” Critical Care Clinics, vol. 17, no. 1, pp. 107–124, 2001. View at Google Scholar · View at Scopus
  9. R. M. Waeschle, O. Moerer, R. Hilgers, P. Herrmann, P. Neumann, and M. Quintel, “The impact of the severity of sepsis on the risk of hypoglycaemia and glycaemic variability,” Critical Care, vol. 12, no. 5, article R129, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. F. M. Brunkhorst, C. Engel, F. Bloos et al., “Intensive insulin therapy and pentastarch resuscitation in severe sepsis,” The New England Journal of Medicine, vol. 358, no. 2, pp. 125–139, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Iapichino, M. Albicini, M. Umbrello et al., “Tight glycemic control does not affect asymmetric-dimethylarginine in septic patients,” Intensive Care Medicine, vol. 34, no. 10, pp. 1843–1850, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Savioli, M. Cugno, F. Polli et al., “Tight glycemic control may favor fibrinolysis in patients with sepsis,” Critical Care Medicine, vol. 37, no. 2, pp. 424–431, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. W.-K. Yu, W.-Q. Li, X.-D. Wang et al., “Influence and mechanism of a tight control of blood glucose by intensive insulin therapy on human sepsis,” Zhonghua Wai Ke Za Zhi, vol. 43, no. 1, pp. 29–32, 2005. View at Google Scholar · View at Scopus
  14. S. B. Cappi, D. T. Noritomi, I. T. Velasco, R. Curi, T. C. A. Loureiro, and F. G. Soriano, “Dyslipidemia: a prospective controlled randomized trial of intensive glycemic control in sepsis,” Intensive Care Medicine, vol. 38, no. 4, pp. 634–641, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Van Den Berghe, P. Wouters, F. Weekers et al., “Intensive insulin therapy in critically ill patients,” The New England Journal of Medicine, vol. 345, no. 19, pp. 1359–1367, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. COIITSS Study Investigators, “Corticosteroid treatment and intensive insulin therapy for septic shock in adults-a randomized controlled trial,” Journal of the American Medical Association, vol. 303, no. 17, pp. 341–348, 2010. View at Google Scholar
  17. The NICE-SUGAR Study Investigators, “Intensive versus conventional glucose control in critically ill patients,” The New England Journal of Medicine, vol. 360, no. 13, pp. 1283–1297, 2009. View at Google Scholar
  18. R. P. Dellinger, M. M. Levy, A. Rhodes et al., “Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012,” Critical Care Medicine, vol. 41, no. 2, pp. 580–637, 2013. View at Google Scholar
  19. S. Green and J. PT Higgins, Cochrane Handbook for Systematic Reviews of Interventions Version 5. 1. 0, The Cochrane Collaboration, 2011.
  20. Review Manager (RevMan) [Computer program], Version 5. 2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
  21. J. A. Berlin, N. M. Laird, H. S. Sacks, and T. C. Chalmers, “A comparison of statistical methods for combining event rates from clinical trials,” Statistics in Medicine, vol. 8, no. 2, pp. 141–151, 1989. View at Google Scholar · View at Scopus
  22. F. Polli, M. Savioli, M. Cugno et al., “Effects of recombinant human activated protein C on the fibrinolytic system of patients undergoing conventional or tight glycemic control,” Minerva Anestesiologica, vol. 75, no. 7-8, pp. 417–426, 2009. View at Google Scholar · View at Scopus
  23. Y. Jin and C. Guolong, “A multicentre study on intensive insulin therapy of severe sepsis and septic shock patients in ICU-collaborative study group on IIT in Zhejiang province, china,” Intensive Care Medicine, vol. 35, Supplement 1, article 86S, 2009. View at Google Scholar
  24. Y. M. Arabi, O. C. Dabbagh, H. M. Tamim et al., “Intensive versus conventional insulin therapy: a randomized controlled trial in medical and surgical critically ill patients,” Critical Care Medicine, vol. 36, no. 12, pp. 3190–3197, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Ellger, M. Westphal, H. D. Stubbe, I. Van Den Heuvel, H. Van Aken, and G. Van Den Berghe, “Glycemic control in sepsis and septic shock. Friend or foe?” Anaesthesist, vol. 57, no. 1, pp. 43–48, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. R.-L. Zhang, W. He, T. Li et al., “Evaluation of optimal goal of glucose control in critically ill patients,” Chinese Journal of Clinical Nutrition, vol. 16, no. 4, pp. 204–208, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. S.-M. Dong, Y.-J. Qin, and Y.-F. Gao, “The influence of intensive insulin therapy on hemodynamics in patients with septic shock,” Chinese Critical Care Medicine, vol. 21, no. 5, pp. 290–292, 2009 (Chinese). View at Publisher · View at Google Scholar · View at Scopus
  28. D. C. Angus, “The search for effective therapy for sepsis: back to the drawing board?” JAMA—Journal of the American Medical Association, vol. 306, no. 23, pp. 2614–2615, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Soylemez Wiener, D. C. Wiener, and R. J. Larson, “Benefits and risks of tight glucose control in critically ill adults: a meta-analysis,” JAMA—Journal of the American Medical Association, vol. 300, no. 8, pp. 933–944, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Kansagara, R. Fu, M. Freeman, F. Wolf, and M. Helfand, “Intensive insulin therapy in hospitalized patients: a systematic review,” Annals of Internal Medicine, vol. 154, no. 4, pp. 268–282, 2011. View at Google Scholar · View at Scopus
  31. D. E. Griesdale, R. J. de Souza, R. M. van Dam et al., “Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data,” Canadian Medical Association Journal, vol. 180, no. 8, pp. 821–827, 2009. View at Google Scholar
  32. G. Van Den Berghe, A. Wilmer, G. Hermans et al., “Intensive insulin therapy in the medical ICU,” The New England Journal of Medicine, vol. 354, no. 5, pp. 449–461, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Finfer, “Clinical controversies in the management of critically ill patients with severe sepsis-Resuscitation fluids and glucose control,” Virulence, vol. 4, no. 8, pp. 1–6, 2013. View at Google Scholar
  34. S. Park, D. G. Kim, G. Y. Suh et al., “Mild hypoglycemia is independently associated with increased risk of mortality in patients with sepsis: a 3-year retrospective observational study,” Critical Care, vol. 16, no. 5, article R189, 2012. View at Google Scholar
  35. N. A. Ali, J. M. O'Brien, K. Dungan et al., “Glucose variability and mortality in patients with sepsis,” Critical Care Medicine, vol. 36, no. 8, pp. 2316–2321, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Hirasawa, S. Oda, and M. Nakamura, “Blood glucose control in patients with severe sepsis and septic shock,” World Journal of Gastroenterology, vol. 15, no. 33, pp. 4132–4136, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. L. Monnier, E. Mas, C. Ginet et al., “Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes,” Journal of the American Medical Association, vol. 295, no. 14, pp. 1681–1687, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. D. C. Angus and T. van der Poll, “Severe sepsis and septic shock,” The New England Journal of Medicine, vol. 369, no. 21, pp. 840–851, 2013. View at Google Scholar