Research Article
Caffeic Acid Phenethyl Ester Protects against Amphotericin B Induced Nephrotoxicity in Rat Model
Table 1
The scores of histological changes of kidney damage in study groups.
| Groups | | Proximal and distal tubular dilatation | Hyperchromatic cell nuclei | Hemorrhagic areas in medulla | Necrotic areas in cortex | Mononuclear cell infiltration in medulla | Mononuclear cell infiltration in cortex | Dilatations/ degenerations in collecting ducts |
| 1-Control | 10 | 0.00 ± 0.00 | 0.30 ± 0.48 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.10 ± 0.32 | 2-CAPE | 9 | 0.11 ± 0.33 | 0.33 ± 0.71 | 0.11 ± 0.33 | 0.00 ± 0.00 | 0.11 ± 0.33 | 0.22 ± 0.44 | 0.22 ± 0.44 | 3-AmB | 7 | 2.86 ± 0.38 | 1.57 ± 0.98 | 1.86 ± 0.69 | 2.00 ± 0.58 | 0.86 ± 0.69 | 2.00 ± 0.58 | 2.57 ± 0.79 | 4-AmB + CAPE | 7 | 1.14 ± 1.07 | 1.00 ± 0.58 | 0.29 ± 0.49 | 0.71 ± 0.49 | 1.14 ± 0.69 | 0.8571 ± 0.6901 | 0.71 ± 0.49 |
| -values | 1-2 | | NS | NS | NS | NS | NS | NS | NS | 1–3 | | 0.0001 | 0.001 | 0.0001 | 0.0001 | 0.001 | 0.0001 | 0.0001 | 1–4 | | 0.0001 | 0.049 | NS | 0.0001 | 0.0001 | 0.001 | 0.21 | 2-3 | | 0.0001 | 0.001 | 0.0001 | 0.0001 | 0.004 | 0.0001 | 0.0001 | 2–4 | | 0.001 | NS | NS | 0.0001 | 0.0001 | 0.012 | NS | 3-4 | | 0.0001 | NS | 0.0001 | 0.0001 | NS |
0.0001 | 0.0001 |
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NS: not significant. Values are expressed as mean ± standard error of mean.
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