Research Article

Caffeic Acid Phenethyl Ester Protects against Amphotericin B Induced Nephrotoxicity in Rat Model

Table 1

The scores of histological changes of kidney damage in study groups.

Groups Proximal and distal tubular dilatationHyperchromatic cell nuclei Hemorrhagic areas in medulla Necrotic areas in cortexMononuclear cell infiltration in medullaMononuclear cell infiltration in cortex Dilatations/
degenerations in collecting ducts

1-Control 100.00 ± 0.000.30 ± 0.480.00 ± 0.000.00 ± 0.000.00 ± 0.000.00 ± 0.000.10 ± 0.32
2-CAPE 90.11 ± 0.330.33 ± 0.710.11 ± 0.330.00 ± 0.000.11 ± 0.330.22 ± 0.440.22 ± 0.44
3-AmB 72.86 ± 0.381.57 ± 0.981.86 ± 0.692.00 ± 0.580.86 ± 0.692.00 ± 0.582.57 ± 0.79
4-AmB + CAPE 71.14 ± 1.071.00 ± 0.580.29 ± 0.490.71 ± 0.491.14 ± 0.690.8571 ± 0.69010.71 ± 0.49

-values
1-2NSNSNSNSNSNSNS
1–30.00010.0010.00010.00010.0010.00010.0001
1–40.00010.049NS 0.00010.00010.0010.21
2-30.00010.0010.00010.00010.0040.00010.0001
2–40.001NS NS0.00010.00010.012NS
3-40.0001NS0.00010.0001NS 0.00010.0001

NS: not significant. Values are expressed as mean ± standard error of mean.