Intracerebroventricular Administration of Nerve Growth Factor Induces Gliogenesis in Sensory Ganglia, Dorsal Root, and within the Dorsal Root Entry Zone
Figure 3
NGF induces a significant increase in the number of proliferating cells within the cervical DRG. Representative BrdU-DAB stainings of cervical DRGs of both the vehicle control (a) and NGF-treated animal (b). Note the massively increased BrdU positive profiles present in the neuronal soma compartment of the NGF-treated animals. Nissl staining of a cervical DRG (c) showing the axonal (Ax) and neuronal soma compartment (Ne). Neuronal soma compartments within the DRG were chosen for quantification of BrdU positive nuclei. Quantification of BrdU positive cells within the neuronal soma compartment across cervical ganglia C5 to C7 (d). Mean ± S.E.M.; *. Scale bar = 200 μm.
