Cardiac Electrophysiological Alterations in Heart/Muscle-Specific Manganese-Superoxide Dismutase-Deficient Mice: Prevention by a Dietary Antioxidant Polyphenol

Figure 1

Effects of chronic apple polyphenols (AP) intake on life span, heart weights, and electrocardiograms (ECG) in control and H/M-Sod2 ^−/− mice. (a) Survival curves of 4 experimental groups. Control, 𝑛=10, control + AP, 𝑛=10, H/M-Sod2 ^−/−, 𝑛=13, H/M-Sod2 ^−/− + AP, 𝑛=15. (b) Heart weight normalized by body weight in 4 experimental groups. Control, 𝑛=8, control + AP, 𝑛=9, H/M-Sod2 ^−/−, 𝑛=15, H/M-Sod2 ^−/− + AP, 𝑛=15. (c) Representative records of surface ECG (lead II) in control and H/M-Sod2 ^−/− mice. (d) QRS durations, (e) PR intervals, and (f) QT intervals of ECG recorded in 4 experimental groups. ((a)–(e)) Control, 𝑛=7, control + AP, 𝑛=10, H/M-Sod2 ^−/−, 𝑛=13, H/M-Sod2 ^−/− + AP, 𝑛=12. (f) Control, 𝑛=7, control + AP, 𝑛=10, H/M-Sod2 ^−/−, 𝑛=7, H/M-Sod2 ^−/− + AP, 𝑛=7. Values are mean ± SEM, ***𝑃<0.001, **𝑃<0.01, *𝑃<0.05.

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