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BioMed Research International
Volume 2014, Article ID 704362, 17 pages
http://dx.doi.org/10.1155/2014/704362
Research Article

Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique

1Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia
2Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
3Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Received 28 February 2014; Revised 10 April 2014; Accepted 10 April 2014; Published 26 May 2014

Academic Editor: Oluwatoyin A. Odeku

Copyright © 2014 Kadria A. Elkhodairy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. K. Chourasia and S. K. Jain, “Pharmaceutical approaches to colon targeted drug delivery systems,” Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 1, pp. 33–66, 2003. View at Google Scholar · View at Scopus
  2. V. R. Sinha and R. Kumria, “Polysaccharides in colon-specific drug delivery,” International Journal of Pharmaceutics, vol. 224, no. 1-2, pp. 19–38, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Bussemer, I. Otto, and R. Bodmeier, “Pulsatile drug-delivery systems,” Critical Reviews in Therapeutic Drug Carrier Systems, vol. 18, no. 5, pp. 433–458, 2001. View at Google Scholar · View at Scopus
  4. M. S. Chavan, V. P. Sant, and M. S. Nagarsenker, “Azo-containing urethane analogues for colonic drug delivery: synthesis, characterization and in-vitro evaluation,” Journal of Pharmacy and Pharmacology, vol. 53, no. 6, pp. 895–900, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. V. R. Vemula, V. Lagishetty, and S. Lingala, “Solubility enhancement techniques,” International Journal of Pharmaceutical Sciences Review and Research, vol. 5, no. 1, pp. 41–51, 2010. View at Google Scholar · View at Scopus
  6. I. Sridhar, A. Doshi, B. Joshi, V. Wankhede, and J. Doshi, “Solid dispersions: an approach to enhance solubility of poorly water soluble drug,” Journal of Scientific and Innovative Research, vol. 2, no. 3, pp. 685–694, 2013. View at Publisher · View at Google Scholar
  7. N. Blagden, M. de Matas, P. T. Gavan, and P. York, “Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates,” Advanced Drug Delivery Reviews, vol. 59, no. 7, pp. 617–630, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Anjumn, A. Farhan, P. Yvonne, and R. M. Afzal, “Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles,” Journal of Basic and Clinical Pharmacy, vol. 2, no. 2, pp. 71–81, 2011. View at Google Scholar
  9. M. L. Hart, D. P. Do, R. A. Ansari, and S. A. A. Rizvi, “Brief overview of various approaches to enhance drug solubility,” Journal of Developing Drugs, vol. 2, no. 3, Article ID 100011, 2013. View at Publisher · View at Google Scholar
  10. J. Reza, “Self-emulsifying drug delivery systems: a review,” International Journal of Pharmaceutical and Life Sciences, vol. 2, no. 2, pp. 80–84, 2013. View at Google Scholar
  11. N. Chella, N. Shastri, and R. R. Tadikonda, “Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan,” Acta Pharmaceutica Sinica B, vol. 2, pp. 502–508, 2012. View at Publisher · View at Google Scholar
  12. S. Spireas and S. M. Bolton, “Liquisolid systems and method of preparing same,” U.S Patent 6096337, 2000.
  13. S. Spireas, Liquisolid System and method of preparing same, U.S Patent 6423339 B1, 2002.
  14. P. Chandel, K. Raj, and A. Kapoor, “Liquisolid technique: an approach for enhancement of solubility,” Journal of Drug Delivery & Therapeutics, vol. 3, no. 4, pp. 131–137, 2013. View at Google Scholar
  15. S. S. Spireas, C. I. Jarowski, and B. D. Rohera, “Powdered solution technology: principles and mechanism,” Pharmaceutical Research, vol. 9, no. 10, pp. 1351–1358, 1992. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Javadzadeh, M. R. Siahi-Shadbad, M. Barzegar-Jalali, and A. Nokhodchi, “Enhancement of dissolution rate of piroxicam using liquisolid compacts,” Farmaco, vol. 60, no. 4, pp. 361–365, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Nokhodchi, C. M. Hentzschel, and C. S. Leopold, “Drug release from liquisolid systems: speed it up, slow it down,” Expert Opinion on Drug Delivery, vol. 8, no. 2, pp. 191–205, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. B. M. El-Houssieny, L. F. Wahman, and N. M. S. Arafa, “Bioavailability and biological activity of liquisolid compact formula of repaglinide and its effect on glucose tolerance in rabbits,” Bioscience Trends, vol. 4, no. 1, pp. 17–24, 2010. View at Google Scholar · View at Scopus
  19. Y. Javadzadeh, B. Jafari-Navimipour, and A. Nokhodchi, “Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine),” International Journal of Pharmaceutics, vol. 341, no. 1-2, pp. 26–34, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. K. A. Khaled, Y. A. Asiri, and Y. M. El-Sayed, “In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs,” International Journal of Pharmaceutics, vol. 222, no. 1, pp. 1–6, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. M. D. Boudreau, K. H. Sohn, S. H. Rhee, S. W. Lee, J. D. Hunt, and D. H. Hwang, “Suppression of tumor cell growth both in nude mice and in culture by n-3 polyunsaturated fatty acids: mediation through cyclooxygenase-independent pathways,” Cancer Research, vol. 61, no. 4, pp. 1386–1391, 2001. View at Google Scholar · View at Scopus
  22. D. J. E. Elder, D. E. Halton, T. E. Crew, and C. Paraskeva, “Apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non- steroidal anti-inflammatory drug NS-398,” International Journal of Cancer, vol. 86, no. 4, pp. 553–560, 2000. View at Google Scholar · View at Scopus
  23. C. Lönnroth, M. Andersson, and K. Lundholm, “Indomethacin and telomerase activity in tumor growth retardation,” International Journal of Oncology, vol. 18, no. 5, pp. 929–937, 2001. View at Google Scholar · View at Scopus
  24. K. Higuchi, E. Umegaki, T. Watanabe et al., “Present status and strategy of NSAIDs-induced small bowel injury,” Journal of Gastroenterology, vol. 44, no. 9, pp. 879–888, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Higuchi and K. A. Connors, “Phase solubility techniques,” Advances in Analytical Chemistry and Instrumentation, vol. 4, pp. 117–212, 1965. View at Google Scholar
  26. S. Spireas and S. M. Bolton, “Liquisolid systems and methods of preparing same,” U.S. Patent 5968550, 1999.
  27. P. E. Luner, L. E. Kirsch, S. Majuru et al., “Preformulation studies on the S-isomer of oxybutynin hydrochloride, an Improved Chemical Entity (ICE),” Drug Development and Industrial Pharmacy, vol. 27, no. 4, pp. 321–329, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. K. A. Khan, “The concept of dissolution efficiency,” Journal of Pharmacy and Pharmacology, vol. 27, no. 1, pp. 48–49, 1975. View at Google Scholar · View at Scopus
  29. Y. S. R. Krishnaiah, P. R. Bhaskar Reddy, V. Satyanarayana, and R. S. Karthikeyan, “Studies on the development of oral colon targeted drug delivery systems for metronidazole in the treatment of amoebiasis,” International Journal of Pharmaceutics, vol. 236, no. 1-2, pp. 43–55, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. V. R. Prasad, Y. S. R. Krishnaiah, and S. Satyanarayana, “In vitro evaluation of guar gum as a carder for colon-specific drug delivery,” Journal of Controlled Release, vol. 51, no. 2-3, pp. 281–287, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. R. W. Korsmeyer, R. Gurny, and E. Doelker, “Mechanisms of solute release from porous hydrophilic polymers,” International Journal of Pharmaceutics, vol. 15, no. 1, pp. 25–35, 1983. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Nokhodchi, Y. Javadzadeh, M. R. Siahi-Shadbad, and M. Barzegar-Jalali, “The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts,” Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 1, pp. 18–25, 2005. View at Google Scholar · View at Scopus
  33. S. Basavoju, D. Boström, and S. P. Velaga, “Indomethacin-saccharin cocrystal: design, synthesis and preliminary pharmaceutical characterization,” Pharmaceutical Research, vol. 25, no. 3, pp. 530–541, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. D. G. Oakenfull, “The chemistry of high-methoxyl pectins,” in The Chemistry and Technology of Pectin, R. H. Walter, Ed., Academic Press, New York, NY, USA, 1991. View at Google Scholar
  35. USP 29- NF 24, Page 3017.
  36. S. I. Ahmed, S. J. Mohan, and Y. M. Rao, “Modulating the release behavior and kinetic evaluation of diclofenac sodium from natural polymers,” International Journal of ChemTech Research, vol. 2, no. 2, pp. 834–841, 2010. View at Google Scholar · View at Scopus
  37. P. Apparao, J. V. Prabhakarreddy, J. Raju, and B. Shashidher, “Formulation and evaluation of gum based matrix tablets of Lamivudine,” Der Pharmacia Sinica, vol. 2, no. 3, pp. 176–192, 2011. View at Google Scholar
  38. A. A. S. Sundar Raj, S. Rubila, R. Jayabalan, and T. V. Ranganathan, “A Review on Pectin: Chemistry due to General Properties of Pectin and its Pharmaceutical Uses,” http://www.omicsonline.org/scientific-reports/srep550.php.
  39. M. Md. Islama, S. Md. Masumb, M. M. Rahmana, A. I. Md. Mollab, A. A. Shaikhc, and S. K. Roy, “Preparation of chitosan from shrimp shell and investigation of its properties,” International Journal of Basic & Applied Sciences, vol. 11, no. 1, pp. 77–80, 2011. View at Google Scholar
  40. M. Chaplin, Water Structure and Behavior: Guar Gum, South Bank University, London, UK, 2006.
  41. S. S. Kadian and S. L. Harikumar, “Eudragit and its pharmaceutical significance. PharmainfoNet,” 2009, http://www.pharmainfo.net/satishsinghkadian/publications/eudragit-and-its.
  42. A. Paharia, A. K. Yadav, G. Rai, S. K. Jain, S. S. Pancholi, and G. P. Agrawal, “Eudragit-coated pectin microspheres of 5-fluorouracil for colon targeting,” AAPS PharmSciTech, vol. 8, no. 1, article 12, 2007. View at Google Scholar · View at Scopus
  43. B. Nath, L. Nath, and P. Kumar, “Preparation and in vitro dissolution profile of zidovudine loaded microspheres made of Eudragit RS 100, RL 100 and their combinations,” Acta Poloniae Pharmaceutica—Drug Research, vol. 68, no. 3, pp. 409–415, 2011. View at Google Scholar · View at Scopus
  44. R. Cortesi, L. Ravani, E. Menegatti, and E. Esposito F Ronconi, “Eudragit microparticles for the release of budesonide: a comparative study,” Indian Journal of Pharmaceutical Sciences, vol. 74, no. 5, pp. 415–421, 2012. View at Google Scholar
  45. A. Akhgari, M. Abbaspour, and M. Moradkhanizadeh, “Combination of pectin and Eudragit RS and Eudragit RL in the matrix of pellets prepared by extrusion-spheronization for possible colonic delivery of 5-aminosalicylic acid,” Jundishapur Journal of Natural Pharmaceutical Products, vol. 8, no. 2, pp. 86–92, 2013. View at Google Scholar
  46. A. Akhgari, H. Afrasiabi Garekani, and F. Sadeghi, “Combination of inulin and time dependent polymethacrylates as a coating system to achieve colonic delivery of indomethacin,” Daru, vol. 17, no. 3, pp. 199–208, 2009. View at Google Scholar · View at Scopus
  47. M. Efentakis and M. Vlachou, “Evaluation of high molecular weight poly(oxyethylene) (Polyox)polymer: studies of flow properties and release rates of furosemide and captopril from controlled-release hard gelatin capsules,” Pharmaceutical Development and Technology, vol. 5, no. 3, pp. 339–346, 2000. View at Publisher · View at Google Scholar · View at Scopus
  48. K. C. Ofokansi and F. C. Kenechukwu, “Formulation development and evaluation of drug release kinetics from colon-targeted ibuprofen tablets based on eudragit RL 100-chitosan inter-polyelectrolyte complexes,” ISRN Pharmaceutics, vol. 2013, Article ID 838403, 8 pages, 2013. View at Publisher · View at Google Scholar
  49. S. J. Shankar, S. B. Gaurav, and B. V. Basavaraj, “Formulation and evaluation of controlled release matrix tablets of an antimicrobial drug,” International Journal of Pharmaceutical Research and Development, vol. 2, no. 10, pp. 8–10, 2010. View at Google Scholar
  50. B. R. Matthews, “Regulatory aspects of stability testing in Europe,” Drug Development and Industrial Pharmacy, vol. 25, no. 7, pp. 831–856, 1999. View at Publisher · View at Google Scholar · View at Scopus