Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique

Table 6

Flow properties of mixtures of tablet components.

Formula’s code	Polymer	Ratio of polymers	Angle of repose	Carr’s index (%)	Hauser ratio
F2*	PEC	—	36.78 ± 0.015	26.66 ± 0.016	1.36 ± 0.016
F2 + E-RL	PEC	—	27.83 ± 0.009	21.46 ± 0.012	1.27 ± 0.013
F2 + E-RL + Mg st : talc 1 : 9	PEC	—	26.32 ± 0.017	21.09 ± 0.011	1.25 ± 0.011
F2 + E-RL (PM)**	PEC	—	25.02 ± 0.022	19.78 ± 0.012	1.13 ± 0.011
F3*	CH	—	40.91 ± 0.019	29.90 ± 0.008	1.42 ± 0.008
F3 + E-RL	CH	—	35.00 ± 0.021	21.20 ± 0.016	1.37 ± 0.016
F3 + E-RL + Mg st : talc 1 : 9	CH	—	33.10 ± 0.014	20.83 ± 0.021	1.32 ± 0.021
F3 + E-RL (PM)**	CH	—	30.20 ± 0.025	20.84 ± 0.020	1.26 ± 0.020
F4*	GG + CH	1 : 3	39.90 ± 0.009	31.67 ± 0.010	1.46 ± 0.011
F4 + E-RL	GG + CH	1 : 3	32.00 ± 0.022	21.47 ± 0.006	1.27 ± 0.007
F4 + E-RL + Mg st : talc 1 : 9	GG + CH	1 : 3	29.45 ± 0.014	21.00 ± 0.013	1.28 ± 0.012
F4 + E-RL (PM)**	GG + CH	1 : 3	26.00 ± 0.021	17.17 ± 0.021	1.20 ± 0.021
F5*	PEC + CH	3 : 1	38.09 ± 0.019	27.50 ± 0.011	1.38 ± 0.011
F5 + E-RL	PEC + CH	3 : 1	30.46 ± 0.100	21.46 ± 0.070	1.27 ± 0.070
F5 + E-RL + Mg st : talc 1 : 9	PEC + CH	3 : 1	28.99 ± 0.022	20.32 ± 0.009	1.24 ± 0.009
F14 + E-RL (PM)**	PEC + CH	3 : 1	28.50 ± 0.120	18.77 ± 0.013	1.21 ± 0.012
F6*	PEC + CH	1 : 3	40.70 ± 0.021	29.00 ± 0.011	1.41 ± 0.011
F6 + E-RL	PEC + CH	1 : 3	33.90 ± 0.017	21.56 ± 0.013	1.20 ± 0.013
F6 + E-RL + Mg st : talc 1 : 9	PEC + CH	1 : 3	30.45 ± 0.110	20.87 ± 0.011	1.25 ± 0.011
F6 + E-RL (PM)**	PEC + CH	1 : 3	29.46 ± 0.009	21.72 ± 0.010	1.18 ± 0.010

F*: liquisolid system.
PM**: physical mixture.