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BioMed Research International
Volume 2014, Article ID 706302, 6 pages
Review Article

Some In Vitro/In Vivo Chemically-Induced Experimental Models of Liver Oxidative Stress in Rats

Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University 2 Dunav Street, 1000 Sofia, Bulgaria

Received 27 April 2013; Accepted 24 October 2013; Published 16 January 2014

Academic Editor: Afaf K. El-Ansary

Copyright © 2014 Rumyana Simeonova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oxidative stress is critically involved in a variety of diseases. Reactive oxygen species (ROS) are highly toxic molecules that are generated during the body's metabolic reactions and can react with and damage some cellular molecules such as lipids, proteins, or DNA. Liver is an important target of the oxidative stress because of its exposure to various prooxidant toxic compounds as well as of its metabolic function and ability to transform some xenobiotics to reactive toxic metabolites (as ROS). To investigate the processes of liver injuries and especially liver oxidative damages there are many experimental models, some of which we discuss further.