Guidelines on Vaccinations in Paediatric Haematology and Oncology Patients

Table 1

Scoring system used for the recommendations.

Strength of recommendation	Quality of evidence
A: strong evidence for efficacy and substantial clinical benefit; strongly recommended	I: evidence from at least one well-executed randomized, controlled trial
B: strong or moderate evidence for efficacy, but only limited clinical benefit; generally recommended	II: evidence from at least one well-designed clinical trial without randomization; cohort or case-controlled analytic studies (preferable more than one centre), from multiple time-series studies; dramatic results of uncontrolled experiments
C: insufficient evidence for efficacy or efficacy does not outweigh possible adverse consequences; optional	III: evidence from opinions of respected authorities based on clinical experience, descriptive studies, or reports of expert committees
D: Moderate evidence against efficacy or for adverse outcome; generally not recommended
E: strong evidence against efficacy or for adverse outcome; never recommended