Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 708593, 11 pages
http://dx.doi.org/10.1155/2014/708593
Research Article

Uptake of Etoposide in CT-26 Cells of Colorectal Cancer Using Folate Targeted Dextran Stearate Polymeric Micelles

1Department of Pharmaceutics, Novel Drug Delivery Systems Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan 81745-359, Iran
2Department of Medicinal Chemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
3Department of Biotechnology, Isfahan Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran

Received 21 September 2013; Accepted 17 November 2013; Published 10 February 2014

Academic Editor: Frederic Lagarce

Copyright © 2014 Jaleh Varshosaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Herszényi and Z. Tulassay, “Epidemiology of gastrointestinal and liver tumors,” European Review for Medical and Pharmacological Sciences, vol. 14, no. 4, pp. 249–258, 2010. View at Google Scholar · View at Scopus
  2. E. Ricevuto, G. Bruera, and P. Marchetti, “General principles of chemotherapy,” European Review for Medical and Pharmacological Sciences, vol. 14, no. 4, pp. 269–271, 2010. View at Google Scholar · View at Scopus
  3. B. H. O'Neil and J. E. Tepper, “Current options for the management of rectal cancer,” Current Treatment Options in Oncology, vol. 8, no. 5, pp. 331–338, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Lamprecht and J.-P. Benoit, “Etoposide nanocarriers suppress glioma cell growth by intracellular drug delivery and simultaneous P-glycoprotein inhibition,” Journal of Controlled Release, vol. 112, no. 2, pp. 208–213, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Masquelier, Q. F. Zhou, A. Gruber, and S. Vitols, “Relationship between daunorubicin concentration and apoptosis induction in leukemic cells,” Biochemical Pharmacology, vol. 67, no. 6, pp. 1047–1056, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. L. H. Reddy, R. K. Sharma, K. Chuttani, A. K. Mishra, and R. R. Murthy, “Etoposide-incorporated tripalmitin nanoparticles with different surface charge: formulation, characterization, radiolabeling, and biodistribution studies,” The AAPS Journal, vol. 6, no. 3, article e23, pp. 55–64, 2004. View at Google Scholar · View at Scopus
  7. L. Harivardhan Reddy, R. K. Sharma, K. Chuttani, A. K. Mishra, and R. S. R. Murthy, “Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice,” Journal of Controlled Release, vol. 105, no. 3, pp. 185–198, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. J.-K. Kim, E. K. Shin, J. H. Park, Y. H. Kim, and J. H. Y. Park, “Antitumor and antimetastatic effects of licochalcone A in mouse models,” Journal of Molecular Medicine, vol. 88, no. 8, pp. 829–838, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Mahmud, X.-B. Xiong, H. M. Aliabadi, and A. Lavasanifar, “Polymeric micelles for drug targeting,” Journal of Drug Targeting, vol. 15, no. 9, pp. 553–584, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. J. F. Ross, H. Wang, F. G. Behm et al., “Folate receptor type beta is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia,” Cancer, vol. 85, no. 2, pp. 348–357, 1999. View at Google Scholar
  11. J. Shia, D. S. Klimstra, J. R. Nitzkorski et al., “Immunohistochemical expression of folate receptor α in colorectal carcinoma: patterns and biological significance,” Human Pathology, vol. 39, no. 4, pp. 498–505, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. H. M. Aliabadi and A. Lavasanifar, “Polymeric micelles for drug delivery,” Expert Opinion on Drug Delivery, vol. 3, no. 1, pp. 139–162, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. S. S. Dhaneshwar, M. Kandpal, N. Gairola, and S. S. Kadam, “Dextran: a promising macromolecular drug carrier,” Indian Journal of Pharmaceutical Sciences, vol. 68, no. 6, pp. 705–714, 2006. View at Google Scholar · View at Scopus
  14. Y.-Z. Du, Q. Weng, H. Yuan, and F.-Q. Hu, “Synthesis and antitumor activity of stearate- g -dextran micelles for intracellular doxorubicin delivery,” ACS Nano, vol. 4, no. 11, pp. 6894–6902, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Varshosaz, F. Hassanzadeh, H. Sadeghi, F. Firozian, and M. Mirian, “Effect of molecular weight and molar ratio of dextran on self-assembly of dextran stearate polymeric micelles as nanocarriers for etoposide,” Journal of Nanomaterials, vol. 2012, Article ID 256657, 10 pages, 2012. View at Publisher · View at Google Scholar
  16. J. M. Benns, A. Maheshwari, D. Y. Furgeson, R. I. Mahato, and S. W. Kim, “Folate-PEG-folate-graft-polyethylenimine-based gene delivery,” Journal of Drug Targeting, vol. 9, no. 2, pp. 123–139, 2001. View at Google Scholar · View at Scopus
  17. P. R. Reddy and V. Venkateswarlu, “Pharmacokinetics and tissue distribution of etoposide delivered in long circulating parenteral emulsion,” Journal of Drug Targeting, vol. 13, no. 10, pp. 543–553, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. C.-L. Zhao, M. A. Winnik, G. Riess, and M. D. Croucher, “Fluorescence probe techniques used to study micelle formation in water-soluble block copolymers,” Langmuir, vol. 6, no. 2, pp. 514–516, 1990. View at Google Scholar · View at Scopus
  19. M. F. Francis, L. Lavoie, F. M. Winnik, and J.-C. Leroux, “Solubilization of cyclosporin A in dextran-g-polyethyleneglycolalkyl ether polymeric micelles,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 56, no. 3, pp. 337–346, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Bian, L. Jia, W. Yu, and M. Liu, “Self-assembled micelles of N-phthaloylchitosan-g-polyvinylpyrrolidone for drug delivery,” Carbohydrate Polymers, vol. 76, no. 3, pp. 454–459, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Nayebsadrian, J. Varshosaz, F. Hassanzadeh, H. Sadeghi, M. Banitalebi, and M. Rostami, “Screening the most effective variables on physical properties of folate-targeted dextran/retinoic acid micelles by Taguchi design,” Journal of Nanomaterials, vol. 2012, Article ID 860691, 7 pages, 2012. View at Publisher · View at Google Scholar
  22. A. Fattahi, M.-A. Golozar, J. Varshosaz, H. Mirmohammad Sadeghi, and M. Fathi, “Preparation and characterization of micelles of oligomeric chitosan linked to all-trans retinoic acid,” Carbohydrate Polymers, vol. 87, no. 2, pp. 1176–1184, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. R. K. Averineni, G. V. Shavi, A. Gurram et al., “PLGA 50:50 nanoparticles of paclitaxel: development, in vitro anti-tumor activity in BT-549 cells and in vivo evaluation,” Bulletin of Materials Science, vol. 35, no. 3, pp. 319–326, 2012. View at Google Scholar
  24. N. Mohammadpour Dounighi, R. Eskandari, M. R. Avadi, H. Zolfagharian, A. Mir Mohammad Sadeghi, and M. Rezayat, “Preparation and in vitro characterization of chitosan nanoparticles containing Mesobuthus eupeus scorpion venom as an antigen delivery system,” Journal of Venomous Animals and Toxins Including Tropical Diseases, vol. 18, no. 1, pp. 44–52, 2012. View at Google Scholar · View at Scopus
  25. R. H. Müller, K. Mäder, and S. Gohla, “Solid lipid nanoparticles (SLN) for controlled drug delivery—a review of the state of the art,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 50, no. 1, pp. 161–177, 2000. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Teixeira, M. J. Alonso, M. M. M. Pinto, and C. M. Barbosa, “Development and characterization of PLGA nanospheres and nanocapsules containing xanthone and 3-methoxyxanthone,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 59, no. 3, pp. 491–500, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. V. Soni, D. V. Kohli, and S. K. Jain, “Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil,” Journal of Drug Targeting, vol. 13, no. 4, pp. 245–250, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Zhao, M. B. Brown, and S. A. Jones, “The effects of particle properties on nanoparticle drug retention and release in dynamic minoxidil foams,” International Journal of Pharmaceutics, vol. 383, no. 1-2, pp. 277–284, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Hossann, T. Wang, M. Wiggenhorn et al., “Size of thermosensitive liposomes influences content release,” Journal of Controlled Release, vol. 147, no. 3, pp. 436–443, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. M. M. A. Abdel-Mottaleb, D. Neumann, and A. Lamprecht, “In vitro drug release mechanism from lipid nanocapsules (LNC),” International Journal of Pharmaceutics, vol. 390, no. 2, pp. 208–213, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Lamprecht, Y. Bouligand, and J.-P. Benoit, “New lipid nanocapsules exhibit sustained release properties for amiodarone,” Journal of Controlled Release, vol. 84, no. 1-2, pp. 59–68, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. H. S. Na, Y. K. Lim, Y.-I. Jeong et al., “Combination antitumor effects of micelle-loaded anticancer drugs in a CT-26 murine colorectal carcinoma model,” International Journal of Pharmaceutics, vol. 383, no. 1-2, pp. 192–200, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. D.-G. Kim, C. Choi, Y.-I. Jeong et al., “All-trans retinoic acid-associated low molecular weight water-soluble chitosan nanoparticles based on ion complex,” Macromolecular Research, vol. 14, no. 1, pp. 66–72, 2006. View at Google Scholar · View at Scopus
  34. O. V. Braginskaja, V. V. Lazarev, I. N. Pershina, K. V. Petrov, L. B. Rubin, and O. V. Tikhonova, “Sodium fluorescein accumulation in cultured cells,” General Physiology and Biophysics, vol. 12, no. 5, pp. 453–464, 1993. View at Google Scholar · View at Scopus
  35. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983. View at Google Scholar · View at Scopus
  36. J. M. Saul, A. Annapragada, J. V. Natarajan, and R. V. Bellamkonda, “Controlled targeting of liposomal doxorubicin via the folate receptor in vitro,” Journal of Controlled Release, vol. 92, no. 1-2, pp. 49–67, 2003. View at Publisher · View at Google Scholar · View at Scopus