Antioxidant Defense Enzyme Genes and Asthma Susceptibility: Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease
Table 3
Genotype frequencies of genes investigated in the present study.
Gene
Polymorphism
Genotypes
Genotype distributions, (%)
Controls
Asthma, entire group
Allergic asthma
Nonallergic asthma
1
2
3
4
5
6
7
8
9
10
11
GPX2
G>A (rs17880492)
GG
210
98.1
207
96.3
152
97.4
52
92.9
GA
4
1.9
8
3.7
4
2.6
4
7.1
AA
0
0.0
0
0.0
0
0.0
0
0.0
GPX3
G>A (rs2070593)
GG
105
49.1
113
52.6
83
53.2
28
50.0
GA
91
42.5
86
40.0
63
40.4
22
39.3
AA
18
8.4
16
7.4
10
6.4
6
10.7
GPX4
C718T (rs713041)
718TT
31
14.5
33
15.3
25
16.0
8
14.3
718TC
110
51.4
102
47.4
77
49.4
23
41.1
718CC
73
34.1
80
37.2
54
34.6
25
44.6
GSR
T>C (rs2551715)
TT
40
18.7
32
14.9
17
10.9*
15
26.8
TC
109
50.9
107
49.8
79
50.6
25
44.6
CC
65
30.4
76
35.3
60
38.5
16
28.6
SOD2
A16V (rs4880)
16AA
59
27.6
49
22.8
34
21.8
15
26.8
16AV
108
50.5
111
51.6
82
52.6
27
48.2
16VV
47
22.0
55
25.6
40
25.6
14
25.0
SOD3
A40T (rs2536512)
40AA
21
9.8
24
11.2
19
12.2
4
7.1
40AT
96
44.9
90
41.9
63
40.4
25
44.6
40TT
97
45.3
101
47.0
74
47.4
27
48.2
PRDX1
C>A (rs17522918)
CC
182
85.0
188
87.4
138
88.5
47
83.9
CA
31
14.5
27
12.6
18
11.5
9
16.1
AA
1
0.5
0
0.0
0
0.0
0
0.0
TXNRD1
C>G (rs1128446)
CC
140
65.4
145
67.4
101
64.7
42
75.0
CG
66
30.8
63
29.3
50
32.1
12
21.4
GG
8
3.7
7
3.3
5
3.2
2
3.6
FMO3
E158K (rs2266782)
158EE
57
26.6
59
27.4
39
25.0
20
35.7
158EK
121
56.5
113
52.6
87
55.8
24
42.9
158KK
36
16.8
43
20.0
30
19.2
12
21.4
TNF
−308G>A (rs1800629)
−308GG
170
79.4
162
75.4
118
75.6
42
75.0
−308GA
40
18.7
51
23.7
37
23.7
13
23.2
−308AA
4
1.9
2
0.9
1
0.6
1
1.8
IL1B
−511C>T (rs16944)
−511CC
114
53.3
91
42.1
67
43.0*
23
41.1
−511CT
76
35.5
105
48.6
75
48.1*
27
48.2
−511TT
24
11.2
20
9.3
14
9.0
6
10.7
IL3
S27P (rs40401)
27SS
120
56.1
104
48.2
77
49.4
25
44.6
27SP
76
35.5
88
40.7
60
38.5
27
48.2
273P
18
8.4
24
11.1
19
12.2
4
7.1
IL3
−15C>T (rs31480)
−15CC
120
56.1
103
47.7
77
49.4
25
44.6
−15CT
77
36.0
89
41.2
60
38.5
27
48.2
−15TT
17
7.9
24
11.1
19
12.2
4
7.1
IL5
C-703T (rs2069812)
−703CC
90
42.1
132
61.1
97
62.2*
31
55.4
−703CT
108
50.5
72
33.3
52
33.3*
20
35.7*
−703TT
16
7.5
12
5.6
7
4.5
5
8.9
IL5RB (CSF2RB)
G1972A (rs131840)
1972GG
136
67.7
160
74.1
118
75.6
39
69.6
1972GA
62
30.9
54
25.0
36
23.1
17
30.4
1972AA
3
1.5
2
0.9
2
1.3
0
0.0
IL9
T113M (rs2069885)
113TT
146
68.2
159
73.6
113
72.4
44
78.6
113TM
59
27.6
55
25.5
41
26.3
12
21.4
113MM
9
4.2
2
0.9
2
1.3
0
0.0
IL13
−1111C>T (rs1800925)
−1111CC
114
53.3
101
47.0
75
48.1
26
46.4
−1111CT
84
39.3
96
44.7
66
42.3
28
50.0
−1111CT
16
7.5
18
8.4
15
9.6
2
3.6
CC16 (SCGB1A1)
A38G (rs11549442)
38AA
25
11.8
28
13.0
23
14.7
5
8.9
38AG
97
45.8
102
47.4
70
44.9
31
55.4
38GG
90
42.5
85
39.5
63
40.4
20
35.7
SERPINA1
E288V (rs17580)
288EE
211
98.6
212
98.1
153
98.1
55
98.2
288EV
3
1.4
4
1.9
3
1.9
1
1.8
288VV
—
—
—
—
—
—
—
—
SERPINA1
D365N (rs143370956)
365DD
210
98.1
214
99.1
153
98.1
55
98.2
365DN
4
1.9
2
0.9
3
1.9
1
1.8
365NN
—
—
—
—
—
—
—
—
SERPINA1
1331G>A (rs11568814)
1331GG
188
87.9
187
86.6
133
85.3
50
89.3
1331GA
25
11.7
29
13.4
23
14.7
6
10.7
1331AA
1
0.5
0
0.0
0
0.0
0
0.0
a difference in genotype frequency between asthmatics and controls.
