Antioxidant Defense Enzyme Genes and Asthma Susceptibility: Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease
Table 5
Associations of genotype combinations with risk of allergic asthma (stratified by gender).
Combinations of genotypes
Allergic asthma
Controls
Chi-square ( value1)
OR (95% CI)
%
%
Men
GPX1 198PL × GPX2 GG
34
53.1
38
36.2
4.66 (0.03)
2.00 (1.06–3.76)
GPX1 198PL × GSR TC
20
31.3
19
18.1
3.88 (0.05)
2.06 (1.00–4.25)
GPX1 198PL × CAT −21AA
7
10.9
2
1.9
4.77 (0.03)
5.40 (1.25–23.42)
GPX1 198PL × GCLM −588CT
12
18.8
6
5.7
5.80 (0.02)
3.64 (1.33–9.96)
GPX1 198PL × IL5 −703CC
18
28.1
13
12.4
6.58 (0.01)
2.77 (1.25–6.14)
GPX2 GG × CAT −21AA
12
18.8
7
6.7
4.67 (0.03)
3.13 (1.19–8.21)
GPX2 GG × IL5 −703CC
38
59.4
44
41.9
4.86 (0.03)
2.03 (1.08–3.81)
GSR CC × IL5 −703CC
17
26.6
11
10.5
7.44 (0.01)
3.09 (1.34–7.13)
CAT −21AA × IL5 −703CC
9
14.1
3
2.9
5.97 (0.01)
5.01 (1.41–17.8)
CAT −21AT × IL5 −703CT
6
9.4
28
26.7
6.36 (0.01)
0.30 (0.12–0.76)
Women
NQO1 187PP × IL5 −703CC
43
46.7
33
30.3
5.75 (0.02)
2.02 (1.13–3.60)
NQO1 187PP × IL5 −703CT
18
19.6
39
35.8
6.46 (0.01)
0.44 (0.23–0.83)
NQO1 187PP × IL5 −703CC
43
46.7
33
30.3
5.75 (0.02)
2.02 (1.13–3.60)
NQO1 187PP × IL5 −703CT
18
19.6
39
35.8
6.46 (0.01)
0.44 (0.23–0.83)
EPHX1 113YY × IL5 −703CT
9
9.8
24
22.0
4.59 (0.03)
0.40 (0.18–0.89)
EPHX1 113YY × IL5 −703CT
9
9.8
24
22.0
4.59 (0.03)
0.40 (0.18–0.89)
GPX1 198PL × GPX4 718TT
11
12.0
4
3.7
3.83 (0.05)
3.31 (1.07–10.22)
GPX1 198PP × CYBA 640AG
13
14.1
31
28.4
5.97 (0.01)
0.41 (0.20–0.85)
GPX4 718TC × CYBA 640AG
18
19.6
43
39.4
9.33 (0.002)*
0.37 (0.20–0.71)
unadjusted value. value of 0.002 (: adjusted for multiple tests) was set as statistically significant (*a statistically significant association).
